膠原蛋白文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 膠原蛋白 相關文獻 9581 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）189 篇，RCT 130 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 189 | 2.0% |
| Level 2 (RCT) | 130 | 1.4% |
| Level 3 (Clinical Trial) | 34 | 0.4% |
| Level 4 (Observational) | 22 | 0.2% |
| Level 5 (Review/Case Report/Other) | 9206 | 96.1% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| skin | 皮膚 | 8497 | 88.7% |
| immune | 免疫調節 | 3700 | 38.6% |
| musculoskeletal | 肌肉骨骼 | 3206 | 33.5% |
| anti_aging | 抗衰老 | 1741 | 18.2% |
| metabolic | 代謝 | 1034 | 10.8% |
| cardiovascular | 心血管 | 601 | 6.3% |
| other | 其他 | 420 | 4.4% |
| digestive | 消化 | 394 | 4.1% |
| energy | 活力 | 286 | 3.0% |
| cognitive | 認知功能 | 116 | 1.2% |
| sexual | 性功能 | 60 | 0.6% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| collagen | 7874 |
| EPA | 2106 |
| iron | 1016 |
| fiber | 1013 |
| stem cell | 734 |
| hyaluronic acid | 462 |
| exosome | 248 |
| calcium | 242 |
| exosomes | 228 |
| NAC | 170 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| EPA + collagen | 1808 |
| collagen + fiber | 958 |
| collagen + iron | 862 |
| collagen + stem cell | 638 |
| collagen + hyaluronic acid | 419 |
| EPA + stem cell | 278 |
| EPA + iron | 275 |
| EPA + fiber | 272 |
| exosome + exosomes | 228 |
| collagen + exosome | 218 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 皮膚 | 免疫調節 | 肌肉骨骼 | 抗衰老 | 代謝 | 心血管 |
|---|---|---|---|---|---|---|---|
| collagen | 7874 | 7874 | 3225 | 2781 | 1539 | 894 | 514 |
| EPA | 2106 | 1936 | 955 | 599 | 327 | 234 | 123 |
| iron | 1016 | 936 | 495 | 273 | 197 | 114 | 59 |
| fiber | 1013 | 984 | 314 | 268 | 228 | 96 | 43 |
| stem cell | 734 | 676 | 326 | 307 | 140 | 72 | 29 |
| hyaluronic acid | 462 | 438 | 193 | 108 | 130 | 34 | 16 |
| exosome | 248 | 234 | 131 | 71 | 64 | 26 | 11 |
| calcium | 242 | 213 | 60 | 119 | 37 | 33 | 13 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 85 | 0.9% |
| Systematic Review | 104 | 1.1% |
| RCT | 130 | 1.4% |
| Clinical Trial | 34 | 0.4% |
| Observational | 22 | 0.2% |
| Review | 666 | 7.0% |
| Case Report | 334 | 3.5% |
| Other | 8206 | 85.6% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- The Effectiveness of Nanofat in the Management of Skin Scars: A Systematic Review. — Aesthetic surgery journal. Open forum, 2025-01-01
- 功效分類：skin
- Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
- 功效分類：skin
- Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies. — Scientific reports, 2025-07-31
- 功效分類：immune, musculoskeletal, skin
- In vivo reflectance confocal microscopy role for early to advanced lentigo maligna melanoma spectrum: A systematic review and pooled analysis. — Journal of the European Academy of Dermatology and Venereology : JEADV, 2025-03-01
- 功效分類：anti_aging, skin
- Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review. — The Japanese dental science review, 2025-12-01
- 功效分類：skin
Level 2 證據（RCT）
- Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
- 功效分類：musculoskeletal, skin
- Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. — Journal of medicinal food, 2022-12-01
- 功效分類：anti_aging, skin
- Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. — Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024-07-01
- 功效分類：anti_aging, skin
- Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. — JCI insight, 2022-10-24
- 功效分類：cognitive, immune, musculoskeletal, skin
- The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A — Frontiers in endocrinology, 2022-01-01
- 功效分類：metabolic, musculoskeletal, skin
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