膠原蛋白文獻薈萃報告 — 2026 年 2 月

摘要

本月共收錄 膠原蛋白 相關文獻 9501 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）189 篇，RCT 130 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	189	2.0%
Level 2 (RCT)	130	1.4%
Level 3 (Clinical Trial)	34	0.4%
Level 4 (Observational)	22	0.2%
Level 5 (Review/Case Report/Other)	9126	96.1%

功效分類統計

功效分類	中文	文獻數	佔比
skin	皮膚	8425	88.7%
immune	免疫調節	3662	38.5%
musculoskeletal	肌肉骨骼	3174	33.4%
anti_aging	抗衰老	1726	18.2%
metabolic	代謝	1029	10.8%
cardiovascular	心血管	596	6.3%
other	其他	419	4.4%
digestive	消化	389	4.1%
energy	活力	283	3.0%
cognitive	認知功能	116	1.2%
sexual	性功能	59	0.6%

成分搭配統計

成分	文獻數
collagen	7803
EPA	2085
fiber	1006
iron	1003
stem cell	726
hyaluronic acid	457
exosome	245
calcium	236
exosomes	225
NAC	167

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
EPA + collagen	1788
collagen + fiber	951
collagen + iron	851
collagen + stem cell	630
collagen + hyaluronic acid	414
EPA + stem cell	275
EPA + iron	271
EPA + fiber	267
exosome + exosomes	225
collagen + exosome	215

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	皮膚	免疫調節	肌肉骨骼	抗衰老	代謝	心血管
collagen	7803	7803	3190	2753	1526	889	509
EPA	2085	1916	942	590	323	233	123
fiber	1006	977	310	265	228	96	43
iron	1003	924	491	268	192	114	58
stem cell	726	668	321	302	138	72	29
hyaluronic acid	457	433	189	105	130	34	16
exosome	245	231	130	70	63	26	11
calcium	236	208	58	114	36	31	12

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	85	0.9%
Systematic Review	104	1.1%
RCT	130	1.4%
Clinical Trial	34	0.4%
Observational	22	0.2%
Review	664	7.0%
Case Report	332	3.5%
Other	8130	85.6%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. The Effectiveness of Nanofat in the Management of Skin Scars: A Systematic Review. — Aesthetic surgery journal. Open forum, 2025-01-01
   • 功效分類：skin
2. Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
   • 功效分類：skin
3. Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies. — Scientific reports, 2025-07-31
   • 功效分類：immune, musculoskeletal, skin
4. In vivo reflectance confocal microscopy role for early to advanced lentigo maligna melanoma spectrum: A systematic review and pooled analysis. — Journal of the European Academy of Dermatology and Venereology : JEADV, 2025-03-01
   • 功效分類：anti_aging, skin
5. Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review. — The Japanese dental science review, 2025-12-01
   • 功效分類：skin

Level 2 證據（RCT）

1. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
   • 功效分類：musculoskeletal, skin
2. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. — Journal of medicinal food, 2022-12-01
   • 功效分類：anti_aging, skin
3. Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. — Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024-07-01
   • 功效分類：anti_aging, skin
4. Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. — JCI insight, 2022-10-24
   • 功效分類：cognitive, immune, musculoskeletal, skin
5. The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A — Frontiers in endocrinology, 2022-01-01
   • 功效分類：metabolic, musculoskeletal, skin