膠原蛋白文獻薈萃報告 — 2026 年 4 月
摘要
本月共收錄 膠原蛋白 相關文獻 9880 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）195 篇，RCT 134 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 195 | 2.0% |
| Level 2 (RCT) | 134 | 1.4% |
| Level 3 (Clinical Trial) | 34 | 0.3% |
| Level 4 (Observational) | 23 | 0.2% |
| Level 5 (Review/Case Report/Other) | 9494 | 96.1% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| skin | 皮膚 | 8753 | 88.6% |
| immune | 免疫調節 | 3853 | 39.0% |
| musculoskeletal | 肌肉骨骼 | 3309 | 33.5% |
| anti_aging | 抗衰老 | 1814 | 18.4% |
| metabolic | 代謝 | 1076 | 10.9% |
| cardiovascular | 心血管 | 620 | 6.3% |
| other | 其他 | 432 | 4.4% |
| digestive | 消化 | 414 | 4.2% |
| energy | 活力 | 298 | 3.0% |
| cognitive | 認知功能 | 120 | 1.2% |
| sexual | 性功能 | 60 | 0.6% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| collagen | 8123 |
| EPA | 2175 |
| iron | 1059 |
| fiber | 1039 |
| stem cell | 754 |
| hyaluronic acid | 479 |
| exosome | 258 |
| calcium | 254 |
| exosomes | 237 |
| NAC | 176 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| EPA + collagen | 1873 |
| collagen + fiber | 981 |
| collagen + iron | 896 |
| collagen + stem cell | 657 |
| collagen + hyaluronic acid | 435 |
| EPA + stem cell | 289 |
| EPA + iron | 284 |
| EPA + fiber | 280 |
| exosome + exosomes | 237 |
| collagen + exosome | 227 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 皮膚 | 免疫調節 | 肌肉骨骼 | 抗衰老 | 代謝 | 心血管 |
|---|---|---|---|---|---|---|---|
| collagen | 8123 | 8123 | 3351 | 2869 | 1605 | 928 | 532 |
| EPA | 2175 | 2003 | 994 | 620 | 344 | 244 | 129 |
| iron | 1059 | 970 | 518 | 284 | 204 | 121 | 64 |
| fiber | 1039 | 1008 | 326 | 278 | 235 | 100 | 44 |
| stem cell | 754 | 695 | 339 | 315 | 144 | 75 | 32 |
| hyaluronic acid | 479 | 454 | 201 | 113 | 139 | 35 | 17 |
| exosome | 258 | 244 | 139 | 71 | 67 | 26 | 12 |
| calcium | 254 | 225 | 63 | 126 | 37 | 35 | 15 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 87 | 0.9% |
| Systematic Review | 108 | 1.1% |
| RCT | 134 | 1.4% |
| Clinical Trial | 34 | 0.3% |
| Observational | 23 | 0.2% |
| Review | 689 | 7.0% |
| Case Report | 335 | 3.4% |
| Other | 8470 | 85.7% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- The Effectiveness of Nanofat in the Management of Skin Scars: A Systematic Review. — Aesthetic surgery journal. Open forum, 2025-01-01
- 功效分類：skin
- Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
- 功效分類：skin
- Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies. — Scientific reports, 2025-07-31
- 功效分類：immune, musculoskeletal, skin
- In vivo reflectance confocal microscopy role for early to advanced lentigo maligna melanoma spectrum: A systematic review and pooled analysis. — Journal of the European Academy of Dermatology and Venereology : JEADV, 2025-03-01
- 功效分類：anti_aging, skin
- Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review. — The Japanese dental science review, 2025-12-01
- 功效分類：skin
Level 2 證據（RCT）
- Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
- 功效分類：musculoskeletal, skin
- Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. — Journal of medicinal food, 2022-12-01
- 功效分類：anti_aging, skin
- Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. — Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024-07-01
- 功效分類：anti_aging, skin
- Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. — JCI insight, 2022-10-24
- 功效分類：cognitive, immune, musculoskeletal, skin
- The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A — Frontiers in endocrinology, 2022-01-01
- 功效分類：metabolic, musculoskeletal, skin
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