膠原蛋白文獻薈萃報告 — 2026 年 6 月
摘要
本月共收錄 膠原蛋白 相關文獻 10757 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）220 篇，RCT 145 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 220 | 2.0% |
| Level 2 (RCT) | 145 | 1.3% |
| Level 3 (Clinical Trial) | 36 | 0.3% |
| Level 4 (Observational) | 24 | 0.2% |
| Level 5 (Review/Case Report/Other) | 10332 | 96.0% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| skin | 皮膚 | 9527 | 88.6% |
| immune | 免疫調節 | 4272 | 39.7% |
| musculoskeletal | 肌肉骨骼 | 3607 | 33.5% |
| anti_aging | 抗衰老 | 1989 | 18.5% |
| metabolic | 代謝 | 1204 | 11.2% |
| cardiovascular | 心血管 | 691 | 6.4% |
| digestive | 消化 | 463 | 4.3% |
| other | 其他 | 460 | 4.3% |
| energy | 活力 | 337 | 3.1% |
| cognitive | 認知功能 | 128 | 1.2% |
| sexual | 性功能 | 65 | 0.6% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| collagen | 8837 |
| EPA | 2380 |
| iron | 1194 |
| fiber | 1101 |
| stem cell | 809 |
| hyaluronic acid | 521 |
| exosome | 291 |
| calcium | 283 |
| exosomes | 265 |
| NAC | 196 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| EPA + collagen | 2050 |
| collagen + fiber | 1039 |
| collagen + iron | 1013 |
| collagen + stem cell | 704 |
| collagen + hyaluronic acid | 469 |
| EPA + iron | 336 |
| EPA + stem cell | 311 |
| EPA + fiber | 294 |
| exosome + exosomes | 265 |
| collagen + exosome | 256 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 皮膚 | 免疫調節 | 肌肉骨骼 | 抗衰老 | 代謝 | 心血管 |
|---|---|---|---|---|---|---|---|
| collagen | 8837 | 8837 | 3707 | 3137 | 1754 | 1039 | 593 |
| EPA | 2380 | 2194 | 1122 | 680 | 386 | 282 | 142 |
| iron | 1194 | 1096 | 599 | 320 | 228 | 144 | 76 |
| fiber | 1101 | 1068 | 352 | 295 | 252 | 111 | 46 |
| stem cell | 809 | 749 | 364 | 329 | 153 | 85 | 34 |
| hyaluronic acid | 521 | 493 | 226 | 123 | 150 | 39 | 17 |
| exosome | 291 | 276 | 156 | 75 | 80 | 30 | 14 |
| calcium | 283 | 252 | 73 | 143 | 41 | 35 | 20 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 95 | 0.9% |
| Systematic Review | 125 | 1.2% |
| RCT | 145 | 1.3% |
| Clinical Trial | 36 | 0.3% |
| Observational | 24 | 0.2% |
| Review | 758 | 7.0% |
| Case Report | 360 | 3.3% |
| Other | 9214 | 85.7% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- The Effectiveness of Nanofat in the Management of Skin Scars: A Systematic Review. — Aesthetic surgery journal. Open forum, 2025-01-01
- 功效分類：skin
- Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
- 功效分類：skin
- Therapeutic effects and mechanisms of Tripterygium wilfordii extracts in rheumatoid arthritis: a systematic review and meta-analysis of preclinical studies. — Scientific reports, 2025-07-31
- 功效分類：immune, musculoskeletal, skin
- In vivo reflectance confocal microscopy role for early to advanced lentigo maligna melanoma spectrum: A systematic review and pooled analysis. — Journal of the European Academy of Dermatology and Venereology : JEADV, 2025-03-01
- 功效分類：anti_aging, skin
- Efficacy of different interventions on the morbidity of the palatal donor area after free gingival graft and connective tissue graft: A systematic review. — The Japanese dental science review, 2025-12-01
- 功效分類：skin
Level 2 證據（RCT）
- Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
- 功效分類：musculoskeletal, skin
- Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. — Journal of medicinal food, 2022-12-01
- 功效分類：anti_aging, skin
- Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. — Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024-07-01
- 功效分類：anti_aging, skin
- Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. — JCI insight, 2022-10-24
- 功效分類：cognitive, immune, musculoskeletal, skin
- The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A — Frontiers in endocrinology, 2022-01-01
- 功效分類：metabolic, musculoskeletal, skin
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