輔酶Q10文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 輔酶Q10 相關文獻 2988 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）119 篇，RCT 62 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 119 | 4.0% |
| Level 2 (RCT) | 62 | 2.1% |
| Level 3 (Clinical Trial) | 9 | 0.3% |
| Level 4 (Observational) | 7 | 0.2% |
| Level 5 (Review/Case Report/Other) | 2791 | 93.4% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 1075 | 36.0% |
| cardiovascular | 心血管 | 698 | 23.4% |
| metabolic | 代謝 | 652 | 21.8% |
| immune | 免疫調節 | 499 | 16.7% |
| cognitive | 認知功能 | 409 | 13.7% |
| energy | 活力 | 325 | 10.9% |
| anti_aging | 抗衰老 | 239 | 8.0% |
| musculoskeletal | 肌肉骨骼 | 237 | 7.9% |
| digestive | 消化 | 149 | 5.0% |
| sexual | 性功能 | 142 | 4.8% |
| skin | 皮膚 | 90 | 3.0% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| coenzyme Q10 | 1056 |
| CoQ10 | 723 |
| iron | 304 |
| EPA | 295 |
| glutathione | 158 |
| vitamin E | 89 |
| NAC | 83 |
| selenium | 83 |
| zinc | 55 |
| stem cell | 53 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| CoQ10 + coenzyme Q10 | 556 |
| EPA + coenzyme Q10 | 153 |
| CoQ10 + EPA | 107 |
| coenzyme Q10 + iron | 85 |
| coenzyme Q10 + glutathione | 84 |
| coenzyme Q10 + vitamin E | 69 |
| CoQ10 + glutathione | 65 |
| CoQ10 + iron | 64 |
| coenzyme Q10 + selenium | 60 |
| glutathione + iron | 43 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 心血管 | 代謝 | 免疫調節 | 其他 | 認知功能 | 活力 |
|---|---|---|---|---|---|---|---|
| coenzyme Q10 | 1056 | 314 | 243 | 285 | 201 | 215 | 134 |
| CoQ10 | 723 | 236 | 175 | 202 | 141 | 133 | 95 |
| iron | 304 | 118 | 106 | 62 | 76 | 42 | 33 |
| EPA | 295 | 94 | 84 | 70 | 75 | 37 | 32 |
| glutathione | 158 | 74 | 49 | 48 | 24 | 26 | 6 |
| vitamin E | 89 | 19 | 19 | 16 | 20 | 17 | 7 |
| NAC | 83 | 32 | 21 | 15 | 27 | 12 | 6 |
| selenium | 83 | 26 | 22 | 18 | 11 | 10 | 11 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 78 | 2.6% |
| Systematic Review | 41 | 1.4% |
| RCT | 62 | 2.1% |
| Clinical Trial | 9 | 0.3% |
| Observational | 7 | 0.2% |
| Review | 448 | 15.0% |
| Case Report | 120 | 4.0% |
| Other | 2223 | 74.4% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Nutrition and bipolar disorder: a systematic review. — Nutritional neuroscience, 2023-07-01
- 功效分類：digestive
- Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. — Future cardiology, 2024-03-11
- 功效分類：cardiovascular
- Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis. — Annals of medicine, 2024-12-01
- 功效分類：sexual
- Effects of coenzyme Q10 analogs on oxidative stress, muscle, and metabolism after exercise: A meta-analysis and systematic review. — The Journal of international medical research, 2026-02-01
- 功效分類：metabolic, musculoskeletal
- Coenzyme Q10 supplementation in multiple sclerosis; A systematic review. — Multiple sclerosis and related disorders, 2025-01-01
- 功效分類：cardiovascular, immune, energy
Level 2 證據（RCT）
- Comparative Study Of Combined Co-Enzyme Q10 And Clomiphene Citrate Vs Clomiphene Citrate Alone For Ovulation Induction In Patients With Polycystic Ovarian Syndrome. — JPMA. The Journal of the Pakistan Medical Association, 2023-07-01
- 功效分類：other
- A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis. — European journal of nutrition, 2021-09-01
- 功效分類：immune
- The effect of dietary supplementation of coenzyme Q10 on reproductive variables of cadmium-challenged male Japanese quails (Coturnix Japonica). — Veterinary medicine and science, 2023-03-01
- 功效分類：metabolic, sexual
- The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia. — Pregnancy hypertension, 2021-08-01
- 功效分類：cardiovascular
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway. — BMC cardiovascular disorders, 2024-01-28
- 功效分類：cardiovascular, immune
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