輔酶Q10文獻薈萃報告 — 2026 年 4 月
摘要
本月共收錄 輔酶Q10 相關文獻 3059 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）121 篇，RCT 65 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 121 | 4.0% |
| Level 2 (RCT) | 65 | 2.1% |
| Level 3 (Clinical Trial) | 9 | 0.3% |
| Level 4 (Observational) | 7 | 0.2% |
| Level 5 (Review/Case Report/Other) | 2857 | 93.4% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 1100 | 36.0% |
| cardiovascular | 心血管 | 717 | 23.4% |
| metabolic | 代謝 | 673 | 22.0% |
| immune | 免疫調節 | 512 | 16.7% |
| cognitive | 認知功能 | 417 | 13.6% |
| energy | 活力 | 333 | 10.9% |
| anti_aging | 抗衰老 | 250 | 8.2% |
| musculoskeletal | 肌肉骨骼 | 240 | 7.8% |
| digestive | 消化 | 154 | 5.0% |
| sexual | 性功能 | 145 | 4.7% |
| skin | 皮膚 | 94 | 3.1% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| coenzyme Q10 | 1085 |
| CoQ10 | 745 |
| iron | 314 |
| EPA | 303 |
| glutathione | 164 |
| vitamin E | 90 |
| NAC | 86 |
| selenium | 84 |
| stem cell | 56 |
| zinc | 56 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| CoQ10 + coenzyme Q10 | 574 |
| EPA + coenzyme Q10 | 157 |
| CoQ10 + EPA | 109 |
| coenzyme Q10 + iron | 90 |
| coenzyme Q10 + glutathione | 87 |
| CoQ10 + iron | 69 |
| coenzyme Q10 + vitamin E | 69 |
| CoQ10 + glutathione | 68 |
| coenzyme Q10 + selenium | 60 |
| glutathione + iron | 45 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 心血管 | 代謝 | 免疫調節 | 其他 | 認知功能 | 活力 |
|---|---|---|---|---|---|---|---|
| coenzyme Q10 | 1085 | 322 | 251 | 293 | 207 | 222 | 140 |
| CoQ10 | 745 | 245 | 181 | 207 | 145 | 137 | 99 |
| iron | 314 | 122 | 111 | 67 | 77 | 43 | 35 |
| EPA | 303 | 98 | 88 | 74 | 77 | 37 | 33 |
| glutathione | 164 | 77 | 53 | 49 | 26 | 26 | 6 |
| vitamin E | 90 | 20 | 20 | 16 | 20 | 17 | 7 |
| NAC | 86 | 33 | 22 | 16 | 28 | 12 | 6 |
| selenium | 84 | 26 | 23 | 18 | 11 | 10 | 11 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 79 | 2.6% |
| Systematic Review | 42 | 1.4% |
| RCT | 65 | 2.1% |
| Clinical Trial | 9 | 0.3% |
| Observational | 7 | 0.2% |
| Review | 463 | 15.1% |
| Case Report | 123 | 4.0% |
| Other | 2271 | 74.2% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Nutrition and bipolar disorder: a systematic review. — Nutritional neuroscience, 2023-07-01
- 功效分類：digestive
- Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. — Future cardiology, 2024-03-11
- 功效分類：cardiovascular
- Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis. — Annals of medicine, 2024-12-01
- 功效分類：sexual
- Effects of Coenzyme Q10 Supplementation on Glycemic Control Biomarkers: An Umbrella Review of Meta-Analyses of Randomised Controlled Trials. — Endocrinology, diabetes & metabolism, 2026-03-01
- 功效分類：metabolic
- Effects of coenzyme Q10 analogs on oxidative stress, muscle, and metabolism after exercise: A meta-analysis and systematic review. — The Journal of international medical research, 2026-02-01
- 功效分類：metabolic, musculoskeletal
Level 2 證據（RCT）
- Comparative Study Of Combined Co-Enzyme Q10 And Clomiphene Citrate Vs Clomiphene Citrate Alone For Ovulation Induction In Patients With Polycystic Ovarian Syndrome. — JPMA. The Journal of the Pakistan Medical Association, 2023-07-01
- 功效分類：other
- A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis. — European journal of nutrition, 2021-09-01
- 功效分類：immune
- The effect of dietary supplementation of coenzyme Q10 on reproductive variables of cadmium-challenged male Japanese quails (Coturnix Japonica). — Veterinary medicine and science, 2023-03-01
- 功效分類：metabolic, sexual
- The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia. — Pregnancy hypertension, 2021-08-01
- 功效分類：cardiovascular
- Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway. — BMC cardiovascular disorders, 2024-01-28
- 功效分類：cardiovascular, immune
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