外泌體文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 外泌體 相關文獻 10565 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）269 篇，RCT 42 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 269 | 2.5% |
| Level 2 (RCT) | 42 | 0.4% |
| Level 3 (Clinical Trial) | 50 | 0.5% |
| Level 4 (Observational) | 36 | 0.3% |
| Level 5 (Review/Case Report/Other) | 10168 | 96.2% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| immune | 免疫調節 | 4119 | 39.0% |
| other | 其他 | 3027 | 28.7% |
| musculoskeletal | 肌肉骨骼 | 2206 | 20.9% |
| anti_aging | 抗衰老 | 1476 | 14.0% |
| cardiovascular | 心血管 | 1182 | 11.2% |
| metabolic | 代謝 | 1163 | 11.0% |
| cognitive | 認知功能 | 1134 | 10.7% |
| skin | 皮膚 | 839 | 7.9% |
| digestive | 消化 | 593 | 5.6% |
| energy | 活力 | 202 | 1.9% |
| sexual | 性功能 | 183 | 1.7% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| stem cell | 5097 |
| EPA | 2212 |
| iron | 1887 |
| exosome | 1781 |
| exosomes | 1491 |
| collagen | 493 |
| calcium | 206 |
| fiber | 156 |
| NAC | 141 |
| hyaluronic acid | 91 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| exosome + exosomes | 1491 |
| EPA + stem cell | 1300 |
| iron + stem cell | 843 |
| exosome + stem cell | 562 |
| exosomes + stem cell | 518 |
| EPA + iron | 492 |
| EPA + exosome | 466 |
| EPA + exosomes | 391 |
| exosome + iron | 380 |
| exosomes + iron | 308 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 免疫調節 | 肌肉骨骼 | 其他 | 抗衰老 | 皮膚 | 心血管 |
|---|---|---|---|---|---|---|---|
| stem cell | 5097 | 1931 | 1450 | 1373 | 746 | 474 | 437 |
| EPA | 2212 | 1044 | 699 | 455 | 321 | 271 | 256 |
| iron | 1887 | 1134 | 457 | 305 | 272 | 153 | 238 |
| exosome | 1781 | 946 | 336 | 338 | 247 | 198 | 331 |
| exosomes | 1491 | 788 | 290 | 294 | 200 | 173 | 281 |
| collagen | 493 | 224 | 191 | - | 85 | 493 | 36 |
| calcium | 206 | 82 | 110 | 27 | 25 | 25 | 32 |
| fiber | 156 | 54 | 72 | 18 | 24 | 41 | 14 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 102 | 1.0% |
| Systematic Review | 167 | 1.6% |
| RCT | 42 | 0.4% |
| Clinical Trial | 50 | 0.5% |
| Observational | 36 | 0.3% |
| Review | 2765 | 26.2% |
| Case Report | 380 | 3.6% |
| Other | 7023 | 66.5% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Molecular Markers of Tumor Invasion in Ameloblastoma: A Systematic Review. — Oral diseases, 2025-10-27
- 功效分類：immune, musculoskeletal
- Primary and secondary stroke prophylaxis in children with sickle cell anemia: a meta-analysis. — Blood advances, 2026-02-10
- 功效分類：other
- Prognostic Biomarkers for Predicting Decompensation in Alcoholic and Nonalcoholic Patients With Compensated Cirrhosis: An Umbrella Review. — Biochemistry research international, 2026-01-01
- 功效分類：anti_aging
- Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
- 功效分類：skin
- Respiratory oscillometry in monitoring lung transplant allograft function: a systematic scoping review. — European respiratory review : an official journal of the European Respiratory Society, 2026-01-01
- 功效分類：other
Level 2 證據（RCT）
- Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple myeloma. — Journal of medical economics, 2026-12-01
- 功效分類：other
- Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium. — Blood, 2026-02-12
- 功效分類：other
- Effects of the DailyColors™ polyphenol supplement on serum proteome, cognitive function, and health in older adults at risk of cognitive and functional decline. — Food & function, 2025-06-03
- 功效分類：cognitive, immune
- Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial. — Stem cell research & therapy, 2025-09-24
- 功效分類：anti_aging, immune, musculoskeletal
- Efficacy and safety of autologous adipose-derived stem cells in subjects with moderate to severe atopic dermatitis: a multicenter, randomized, single-blind, placebo-controlled, phase 2 trial. — Stem cell research & therapy, 2025-12-02
- 功效分類：immune, skin
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