外泌體文獻薈萃報告 — 2026 年 4 月
摘要
本月共收錄 外泌體 相關文獻 12604 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）331 篇，RCT 44 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 331 | 2.6% |
| Level 2 (RCT) | 44 | 0.3% |
| Level 3 (Clinical Trial) | 52 | 0.4% |
| Level 4 (Observational) | 39 | 0.3% |
| Level 5 (Review/Case Report/Other) | 12138 | 96.3% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| immune | 免疫調節 | 4964 | 39.4% |
| other | 其他 | 3579 | 28.4% |
| musculoskeletal | 肌肉骨骼 | 2640 | 20.9% |
| anti_aging | 抗衰老 | 1796 | 14.2% |
| cardiovascular | 心血管 | 1437 | 11.4% |
| metabolic | 代謝 | 1367 | 10.8% |
| cognitive | 認知功能 | 1357 | 10.8% |
| skin | 皮膚 | 995 | 7.9% |
| digestive | 消化 | 715 | 5.7% |
| energy | 活力 | 246 | 2.0% |
| sexual | 性功能 | 218 | 1.7% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| stem cell | 6070 |
| EPA | 2638 |
| iron | 2263 |
| exosome | 2088 |
| exosomes | 1742 |
| collagen | 581 |
| calcium | 246 |
| NAC | 182 |
| fiber | 182 |
| hyaluronic acid | 105 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| exosome + exosomes | 1742 |
| EPA + stem cell | 1527 |
| iron + stem cell | 1013 |
| exosome + stem cell | 650 |
| exosomes + stem cell | 598 |
| EPA + iron | 587 |
| EPA + exosome | 545 |
| EPA + exosomes | 457 |
| exosome + iron | 455 |
| exosomes + iron | 369 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 免疫調節 | 肌肉骨骼 | 其他 | 抗衰老 | 皮膚 | 心血管 |
|---|---|---|---|---|---|---|---|
| stem cell | 6070 | 2313 | 1721 | 1629 | 904 | 555 | 510 |
| EPA | 2638 | 1260 | 823 | 530 | 393 | 322 | 317 |
| iron | 2263 | 1382 | 539 | 356 | 339 | 182 | 283 |
| exosome | 2088 | 1127 | 397 | 392 | 293 | 231 | 390 |
| exosomes | 1742 | 930 | 344 | 340 | 237 | 203 | 331 |
| collagen | 581 | 269 | 221 | - | 100 | 581 | 45 |
| calcium | 246 | 99 | 129 | 33 | 31 | 30 | 38 |
| NAC | 182 | 67 | 28 | 59 | 22 | 9 | 25 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 128 | 1.0% |
| Systematic Review | 203 | 1.6% |
| RCT | 44 | 0.3% |
| Clinical Trial | 52 | 0.4% |
| Observational | 39 | 0.3% |
| Review | 3293 | 26.1% |
| Case Report | 453 | 3.6% |
| Other | 8392 | 66.6% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Molecular Markers of Tumor Invasion in Ameloblastoma: A Systematic Review. — Oral diseases, 2025-10-27
- 功效分類：immune, musculoskeletal
- The efficacy and safety of MSCs in GVHD prevention and the treatment of SR-aGVHD: a systematic review and meta-analysis of randomized controlled trials. — Stem cell research & therapy, 2026-03-05
- 功效分類：immune
- Primary and secondary stroke prophylaxis in children with sickle cell anemia: a meta-analysis. — Blood advances, 2026-02-10
- 功效分類：other
- Prognostic Biomarkers for Predicting Decompensation in Alcoholic and Nonalcoholic Patients With Compensated Cirrhosis: An Umbrella Review. — Biochemistry research international, 2026-01-01
- 功效分類：anti_aging
- Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells. — Aesthetic plastic surgery, 2025-10-16
- 功效分類：skin
Level 2 證據（RCT）
- Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple myeloma. — Journal of medical economics, 2026-12-01
- 功效分類：other
- Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium. — Blood, 2026-02-12
- 功效分類：other
- Effects of the DailyColors™ polyphenol supplement on serum proteome, cognitive function, and health in older adults at risk of cognitive and functional decline. — Food & function, 2025-06-03
- 功效分類：cognitive, immune
- Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial. — Stem cell research & therapy, 2025-09-24
- 功效分類：anti_aging, immune, musculoskeletal
- Efficacy and safety of autologous adipose-derived stem cells in subjects with moderate to severe atopic dermatitis: a multicenter, randomized, single-blind, placebo-controlled, phase 2 trial. — Stem cell research & therapy, 2025-12-02
- 功效分類：immune, skin
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