外泌體文獻薈萃報告 — 2026 年 6 月
摘要
本月共收錄 外泌體 相關文獻 18834 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）490 篇，RCT 59 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 490 | 2.6% |
| Level 2 (RCT) | 59 | 0.3% |
| Level 3 (Clinical Trial) | 78 | 0.4% |
| Level 4 (Observational) | 50 | 0.3% |
| Level 5 (Review/Case Report/Other) | 18157 | 96.4% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| immune | 免疫調節 | 7575 | 40.2% |
| other | 其他 | 5247 | 27.9% |
| musculoskeletal | 肌肉骨骼 | 3889 | 20.6% |
| anti_aging | 抗衰老 | 2696 | 14.3% |
| cardiovascular | 心血管 | 2165 | 11.5% |
| metabolic | 代謝 | 2078 | 11.0% |
| cognitive | 認知功能 | 2056 | 10.9% |
| skin | 皮膚 | 1457 | 7.7% |
| digestive | 消化 | 1084 | 5.8% |
| energy | 活力 | 385 | 2.0% |
| sexual | 性功能 | 338 | 1.8% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| stem cell | 8941 |
| EPA | 3972 |
| iron | 3551 |
| exosome | 3065 |
| exosomes | 2537 |
| collagen | 854 |
| calcium | 359 |
| fiber | 279 |
| NAC | 260 |
| hyaluronic acid | 158 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| exosome + exosomes | 2537 |
| EPA + stem cell | 2240 |
| iron + stem cell | 1544 |
| exosome + stem cell | 949 |
| EPA + iron | 916 |
| exosomes + stem cell | 869 |
| EPA + exosome | 808 |
| exosome + iron | 708 |
| EPA + exosomes | 670 |
| exosomes + iron | 572 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 免疫調節 | 肌肉骨骼 | 其他 | 抗衰老 | 皮膚 | 心血管 |
|---|---|---|---|---|---|---|---|
| stem cell | 8941 | 3476 | 2471 | 2339 | 1295 | 814 | 751 |
| EPA | 3972 | 1925 | 1189 | 785 | 608 | 473 | 493 |
| iron | 3551 | 2207 | 828 | 524 | 524 | 289 | 451 |
| exosome | 3065 | 1670 | 561 | 578 | 436 | 339 | 573 |
| exosomes | 2537 | 1364 | 488 | 494 | 350 | 293 | 470 |
| collagen | 854 | 390 | 313 | - | 142 | 854 | 68 |
| calcium | 359 | 137 | 179 | 53 | 49 | 39 | 56 |
| fiber | 279 | 90 | 126 | 41 | 41 | 78 | 26 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 188 | 1.0% |
| Systematic Review | 302 | 1.6% |
| RCT | 59 | 0.3% |
| Clinical Trial | 78 | 0.4% |
| Observational | 50 | 0.3% |
| Review | 5041 | 26.8% |
| Case Report | 680 | 3.6% |
| Other | 12436 | 66.0% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Molecular Markers of Tumor Invasion in Ameloblastoma: A Systematic Review. — Oral diseases, 2025-10-27
- 功效分類：immune, musculoskeletal
- The efficacy and safety of MSCs in GVHD prevention and the treatment of SR-aGVHD: a systematic review and meta-analysis of randomized controlled trials. — Stem cell research & therapy, 2026-03-05
- 功效分類：immune
- Comparative efficacy and safety of antifungal prophylactic agents in allogeneic hematopoietic stem cell transplantation: A systematic review and network meta-analysis. — International journal of antimicrobial agents, 2026-04-27
- 功效分類：other
- A Systematic Review on Disease-Modifying Therapies in Parkinsonian Disorders. — Clinical pharmacology and therapeutics, 2026-05-09
- 功效分類：anti_aging, cognitive, immune
- Neuroinflammatory and Synaptic Roles of Glial Cells in Autism Spectrum Disorder. — CNS & neurological disorders drug targets, 2026-05-08
- 功效分類：immune, metabolic
Level 2 證據（RCT）
- Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple myeloma. — Journal of medical economics, 2026-12-01
- 功效分類：other
- Development and Validation of Flow Cytometry-Based Method to Quantify CD34/CD45+ Cells as a Release Criterion of Clinical-Grade Products for a Phase III Clinical Trial. — Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2026-04-01
- 功效分類：other
- Early time to relapse as a survival prognosticator in nodal mature T-cell lymphomas: results from the PETAL consortium. — Blood, 2026-02-12
- 功效分類：other
- Effects of the DailyColors™ polyphenol supplement on serum proteome, cognitive function, and health in older adults at risk of cognitive and functional decline. — Food & function, 2025-06-03
- 功效分類：cognitive, immune
- Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial. — Stem cell research & therapy, 2025-09-24
- 功效分類：anti_aging, immune, musculoskeletal
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