魚油文獻薈萃報告 — 2026 年 2 月

摘要

本月共收錄 魚油 相關文獻 1845 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）104 篇，RCT 37 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	104	5.6%
Level 2 (RCT)	37	2.0%
Level 3 (Clinical Trial)	5	0.3%
Level 4 (Observational)	11	0.6%
Level 5 (Review/Case Report/Other)	1688	91.5%

功效分類統計

功效分類	中文	文獻數	佔比
other	其他	617	33.4%
cardiovascular	心血管	607	32.9%
immune	免疫調節	485	26.3%
metabolic	代謝	410	22.2%
cognitive	認知功能	241	13.1%
digestive	消化	211	11.4%
anti_aging	抗衰老	185	10.0%
musculoskeletal	肌肉骨骼	156	8.5%
energy	活力	106	5.7%
skin	皮膚	47	2.5%
sexual	性功能	44	2.4%

成分搭配統計

成分	文獻數
EPA	635
omega-3	590
DHA	451
iron	338
fish oil	142
omega-6	83
fiber	66
vitamin D	63
probiotics	61
glutathione	49

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
DHA + EPA	204
EPA + iron	164
EPA + omega-3	147
DHA + omega-3	137
omega-3 + omega-6	75
iron + omega-3	72
EPA + fish oil	57
DHA + iron	56
omega-3 + probiotics	49
omega-3 + vitamin D	48

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	心血管	免疫調節	其他	代謝	認知功能	消化
EPA	635	212	142	251	140	49	54
omega-3	590	210	256	87	169	132	114
DHA	451	197	150	101	114	83	29
iron	338	85	60	149	58	32	32
fish oil	142	71	42	28	34	19	27
omega-6	83	45	40	10	29	9	7
fiber	66	24	29	12	20	13	28
vitamin D	63	21	21	11	19	11	21

進階研究方向

SPM (Specialized Pro-resolving Mediators)

EPA/DHA 的內源性代謝產物，負責主動消炎解析

相關文獻數：63 篇

類型	文獻數	說明
Resolvins	44	E-series (EPA 來源), D-series (DHA 來源)
Protectins	31	神經保護，如 NPD1
Maresins	12	巨噬細胞調節，促進組織修復

代表性文獻：

1. Data showing effects of resolvin D — Data in brief, 2025-12-01
2. The mechanisms of specialized pro-resolving mediators in pain relief: neuro-immune and neuroglial regulations. — Frontiers in immunology, 2025-01-01
3. Oxylipins in Atherosclerosis: Their Role in Inflammation, Diagnosis, and Therapeutic Perspectives. — International journal of molecular sciences, 2025-10-30
4. Sustainable Use of Agro-Industrial By-Products as Feed in Finishing Pigs. — Veterinary sciences, 2026-01-02
5. NPD1/GPR37 signaling protects against painful traumatic brain injury and comorbidities by regulating demyelination, glial responses, and neuroinflammation in the mouse brain. — Brain, behavior, and immunity, 2026-02-01

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	58	3.1%
Systematic Review	46	2.5%
RCT	37	2.0%
Clinical Trial	5	0.3%
Observational	11	0.6%
Review	258	14.0%
Case Report	9	0.5%
Other	1421	77.0%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. Maternal and cord blood lipidomics as predictors of autism spectrum disorders: A systematic review. — Metabolism open, 2025-12-01
   • 功效分類：cardiovascular, immune, metabolic
2. Docosahexaenoic acid supplementation in phenylketonuria: a systematic review. — Frontiers in nutrition, 2025-01-01
   • 功效分類：cognitive, metabolic
3. Omega-3 Polyunsaturated Fatty Acids and Cognitive Decline in Adults with Non-Dementia or Mild Cognitive Impairment: An Overview of Systematic Reviews. — Nutrients, 2025-09-19
   • 功效分類：anti_aging, cognitive, immune
4. Effects of Eicosapentaenoic Acid vs Eicosapentaenoic/Docosahexaenoic Acids on Cardiovascular Mortality: Meta-Analysis of Clinical Trials. — JACC. Advances, 2025-10-01
   • 功效分類：cardiovascular
5. Lead exposure and antisocial behavior: A systematic review of human and animal evidence. — Environment international, 2025-11-01
   • 功效分類：anti_aging

Level 2 證據（RCT）

1. Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich — Nutrients, 2025-08-05
   • 功效分類：cardiovascular, metabolic, musculoskeletal
2. Effects of Prenatal DHA Dose on Infant Visual Attention. — Developmental psychobiology, 2025-09-01
   • 功效分類：cardiovascular, cognitive
3. Effects of diacylglycerol-enriched alpha-linolenic acid oil on skin properties in mild skin discomfort: a randomized, double-blind, placebo-controlled study. — Scientific reports, 2026-01-06
   • 功效分類：immune, skin
4. Association between non-adherence to fish oil or placebo as a risk factor of transition to psychosis in ultra-high-risk individuals in the NEURAPRO study. — The Australian and New Zealand journal of psychiatry, 2025-10-01
   • 功效分類：other
5. Assessing a Panel of Biomarkers in Plasma Reflecting Dietary Intakes: Data From a Large Randomized Controlled Trial. — Molecular nutrition & food research, 2026-01-01
   • 功效分類：other