魚油文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 魚油 相關文獻 9759 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）398 篇，RCT 102 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 398 | 4.1% |
| Level 2 (RCT) | 102 | 1.0% |
| Level 3 (Clinical Trial) | 20 | 0.2% |
| Level 4 (Observational) | 37 | 0.4% |
| Level 5 (Review/Case Report/Other) | 9202 | 94.3% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 4181 | 42.8% |
| immune | 免疫調節 | 2124 | 21.8% |
| cardiovascular | 心血管 | 1571 | 16.1% |
| anti_aging | 抗衰老 | 1307 | 13.4% |
| metabolic | 代謝 | 1256 | 12.9% |
| cognitive | 認知功能 | 1045 | 10.7% |
| musculoskeletal | 肌肉骨骼 | 752 | 7.7% |
| digestive | 消化 | 721 | 7.4% |
| energy | 活力 | 527 | 5.4% |
| skin | 皮膚 | 362 | 3.7% |
| sexual | 性功能 | 208 | 2.1% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| protectin | 3342 |
| resolvin | 2679 |
| EPA | 2039 |
| iron | 1607 |
| omega-3 | 858 |
| DHA | 674 |
| NAC | 247 |
| fish oil | 201 |
| fiber | 192 |
| calcium | 160 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| iron + protectin | 689 |
| EPA + resolvin | 541 |
| EPA + protectin | 515 |
| EPA + iron | 391 |
| iron + resolvin | 331 |
| DHA + EPA | 306 |
| EPA + omega-3 | 214 |
| DHA + omega-3 | 198 |
| pro-resolving + resolvin | 130 |
| iron + omega-3 | 110 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 免疫調節 | 心血管 | 抗衰老 | 代謝 | 認知功能 |
|---|---|---|---|---|---|---|---|
| protectin | 3342 | 1394 | 812 | 405 | 451 | 420 | 392 |
| resolvin | 2679 | 1180 | 518 | 256 | 526 | 189 | 263 |
| EPA | 2039 | 829 | 536 | 445 | 260 | 338 | 144 |
| iron | 1607 | 750 | 297 | 209 | 194 | 187 | 143 |
| omega-3 | 858 | 136 | 382 | 293 | 132 | 241 | 181 |
| DHA | 674 | 156 | 217 | 281 | 58 | 165 | 117 |
| NAC | 247 | 122 | 46 | 27 | 28 | 23 | 20 |
| fish oil | 201 | 41 | 63 | 96 | 11 | 52 | 25 |
進階研究方向
SPM (Specialized Pro-resolving Mediators)
EPA/DHA 的內源性代謝產物，負責主動消炎解析
相關文獻數：6072 篇
| 類型 | 文獻數 | 說明 |
|---|---|---|
| Resolvins | 3846 | E-series (EPA 來源), D-series (DHA 來源) |
| Protectins | 3373 | 神經保護，如 NPD1 |
| Maresins | 36 | 巨噬細胞調節，促進組織修復 |
代表性文獻：
- NeuroDepth: an ultra long whole brain reachable multi-channel probe for real-time precise functional localization of deep human brain tumor margins. — Microsystems & nanoengineering, 2025-12-11
- Lipid Nanoparticle Development in Practice: Challenges and Collective Insights. — Pharmaceutical research, 2026-01-22
- Disrupting the TRAF1/cIAP2 interaction attenuates inflammasome activation and protects against monosodium urate crystal-induced arthritis. — ImmunoHorizons, 2025-11-24
- MCM8/9 and FANCD2 interact within a shared pathway in response to replication stress caused by DNA crosslinks. — DNA repair, 2025-11-01
- Exogenous uromodulin and tubular responses in a model of oxalate-induced kidney injury. — American journal of physiology. Renal physiology, 2025-10-01
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 182 | 1.9% |
| Systematic Review | 216 | 2.2% |
| RCT | 102 | 1.0% |
| Clinical Trial | 20 | 0.2% |
| Observational | 37 | 0.4% |
| Review | 1442 | 14.8% |
| Case Report | 297 | 3.0% |
| Other | 7463 | 76.5% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Harnessing Artificial Intelligence in Interventional Cardiology: A Systematic Review of Current Applications. — Cureus, 2025-07-01
- 功效分類：anti_aging, cardiovascular
- Method of invigorating spleen and replenishing kidney and resolving phlegm for obesity-type polycystic ovary syndrome: a network meta-analysis and summary of herbal prescription regularity. — Frontiers in medicine, 2025-01-01
- 功效分類：metabolic, sexual
- Efficacy and Safety of Erector Spinae Plane Block in Pain Management for Inguinal Hernia Repair: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. — World journal of surgery, 2025-11-01
- 功效分類：other
- Maternal and cord blood lipidomics as predictors of autism spectrum disorders: A systematic review. — Metabolism open, 2025-12-01
- 功效分類：cardiovascular, immune, metabolic
- Emergence and spread of Hyalomma ticks and Crimean-Congo haemorrhagic fever in Europe: a systematic review. — Parasites & vectors, 2025-10-28
- 功效分類：other
Level 2 證據（RCT）
- Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich — Nutrients, 2025-08-05
- 功效分類：cardiovascular, metabolic, musculoskeletal
- Impact of collaborative pharmaceutical care on older inpatients’ medication safety: multicentre stepped-wedge cluster randomised trial (MEDREV Study). — BMC geriatrics, 2025-07-11
- 功效分類：other
- High dose arachidonic and docosahexaenoic acid in very preterm infants and neurodevelopment at 2 years - A double-blind randomized controlled trial. — Clinical nutrition (Edinburgh, Scotland), 2025-08-01
- 功效分類：cardiovascular, cognitive
- Supplementation of Omega-3 Increases Serum Levels of Brain-Derived Neurotrophic Factor and Decreases Depression Status in Patients With Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. — Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025-06-01
- 功效分類：cognitive
- Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides. — Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2025-08-01
- 功效分類：immune, digestive
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