魚油文獻薈萃報告 — 2026 年 6 月
摘要
本月共收錄 魚油 相關文獻 14549 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）584 篇，RCT 134 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 584 | 4.0% |
| Level 2 (RCT) | 134 | 0.9% |
| Level 3 (Clinical Trial) | 32 | 0.2% |
| Level 4 (Observational) | 47 | 0.3% |
| Level 5 (Review/Case Report/Other) | 13752 | 94.5% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 6229 | 42.8% |
| immune | 免疫調節 | 3158 | 21.7% |
| cardiovascular | 心血管 | 2385 | 16.4% |
| anti_aging | 抗衰老 | 1925 | 13.2% |
| metabolic | 代謝 | 1888 | 13.0% |
| cognitive | 認知功能 | 1549 | 10.6% |
| musculoskeletal | 肌肉骨骼 | 1162 | 8.0% |
| digestive | 消化 | 1082 | 7.4% |
| energy | 活力 | 804 | 5.5% |
| skin | 皮膚 | 565 | 3.9% |
| sexual | 性功能 | 307 | 2.1% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| protectin | 4858 |
| resolvin | 4176 |
| EPA | 3037 |
| iron | 2414 |
| omega-3 | 1248 |
| DHA | 1007 |
| NAC | 374 |
| fish oil | 302 |
| fiber | 262 |
| pro-resolving | 234 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| iron + protectin | 1017 |
| EPA + resolvin | 834 |
| EPA + protectin | 748 |
| EPA + iron | 586 |
| iron + resolvin | 544 |
| DHA + EPA | 461 |
| EPA + omega-3 | 317 |
| DHA + omega-3 | 288 |
| pro-resolving + resolvin | 234 |
| omega-3 + omega-6 | 168 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 免疫調節 | 心血管 | 抗衰老 | 代謝 | 認知功能 |
|---|---|---|---|---|---|---|---|
| protectin | 4858 | 2052 | 1153 | 576 | 654 | 602 | 567 |
| resolvin | 4176 | 1794 | 836 | 434 | 799 | 316 | 422 |
| EPA | 3037 | 1232 | 786 | 666 | 380 | 494 | 221 |
| iron | 2414 | 1083 | 487 | 346 | 295 | 298 | 219 |
| omega-3 | 1248 | 187 | 571 | 465 | 185 | 359 | 261 |
| DHA | 1007 | 249 | 313 | 414 | 90 | 243 | 169 |
| NAC | 374 | 183 | 67 | 49 | 42 | 36 | 34 |
| fish oil | 302 | 67 | 94 | 140 | 17 | 69 | 35 |
進階研究方向
SPM (Specialized Pro-resolving Mediators)
EPA/DHA 的內源性代謝產物，負責主動消炎解析
相關文獻數：9077 篇
| 類型 | 文獻數 | 說明 |
|---|---|---|
| Resolvins | 5876 | E-series (EPA 來源), D-series (DHA 來源) |
| Protectins | 4889 | 神經保護，如 NPD1 |
| Maresins | 57 | 巨噬細胞調節，促進組織修復 |
代表性文獻：
- NeuroDepth: an ultra long whole brain reachable multi-channel probe for real-time precise functional localization of deep human brain tumor margins. — Microsystems & nanoengineering, 2025-12-11
- Clearing the Noise: Seasonal Dynamics of Endophytic Bacteria in Fagus sylvatica Leaves Revealed by Application of PNA Clamps. — Physiologia plantarum, 2026-01-01
- Lipid Nanoparticle Development in Practice: Challenges and Collective Insights. — Pharmaceutical research, 2026-01-22
- A Validation of Spatially Compounded Volumetric Ultrasound Localization Microscopy for Glomerular Imaging With Light Sheet Microscopy. — Ultrasound in medicine & biology, 2026-06-09
- RNA-guided clarity: The potential for resolving variant uncertainty in clinical exome sequencing. — Genetics in medicine open, 2026-01-01
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 262 | 1.8% |
| Systematic Review | 322 | 2.2% |
| RCT | 134 | 0.9% |
| Clinical Trial | 32 | 0.2% |
| Observational | 47 | 0.3% |
| Review | 2130 | 14.6% |
| Case Report | 403 | 2.8% |
| Other | 11219 | 77.1% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Harnessing Artificial Intelligence in Interventional Cardiology: A Systematic Review of Current Applications. — Cureus, 2025-07-01
- 功效分類：anti_aging, cardiovascular
- Immunonutrition in surgical patients with colorectal cancer: a systematic review. — Nutricion hospitalaria, 2026-04-15
- 功效分類：immune
- Method of invigorating spleen and replenishing kidney and resolving phlegm for obesity-type polycystic ovary syndrome: a network meta-analysis and summary of herbal prescription regularity. — Frontiers in medicine, 2025-01-01
- 功效分類：metabolic, sexual
- The Role of Immunological Bystander Reaction in Recurrent Pregnancy Loss. — Cureus, 2026-03-01
- 功效分類：cardiovascular, immune
- Efficacy and Safety of Erector Spinae Plane Block in Pain Management for Inguinal Hernia Repair: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. — World journal of surgery, 2025-11-01
- 功效分類：other
Level 2 證據（RCT）
- Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich — Nutrients, 2025-08-05
- 功效分類：cardiovascular, metabolic, musculoskeletal
- Impact of collaborative pharmaceutical care on older inpatients’ medication safety: multicentre stepped-wedge cluster randomised trial (MEDREV Study). — BMC geriatrics, 2025-07-11
- 功效分類：other
- High dose arachidonic and docosahexaenoic acid in very preterm infants and neurodevelopment at 2 years - A double-blind randomized controlled trial. — Clinical nutrition (Edinburgh, Scotland), 2025-08-01
- 功效分類：cardiovascular, cognitive
- Supplementation of Omega-3 Increases Serum Levels of Brain-Derived Neurotrophic Factor and Decreases Depression Status in Patients With Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. — Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025-06-01
- 功效分類：cognitive
- Does the addition of peripheral nerve blocks improve analgesia during distal radius fracture reduction? A prospective, randomized, multicenter clinical trial. — European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026-06-15
- 功效分類：metabolic
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