葉酸文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 葉酸 相關文獻 456 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）29 篇，RCT 9 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 29 | 6.4% |
| Level 2 (RCT) | 9 | 2.0% |
| Level 3 (Clinical Trial) | 2 | 0.4% |
| Level 4 (Observational) | 1 | 0.2% |
| Level 5 (Review/Case Report/Other) | 415 | 91.0% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 188 | 41.2% |
| metabolic | 代謝 | 105 | 23.0% |
| immune | 免疫調節 | 81 | 17.8% |
| cardiovascular | 心血管 | 56 | 12.3% |
| cognitive | 認知功能 | 55 | 12.1% |
| anti_aging | 抗衰老 | 48 | 10.5% |
| musculoskeletal | 肌肉骨骼 | 40 | 8.8% |
| digestive | 消化 | 32 | 7.0% |
| energy | 活力 | 24 | 5.3% |
| skin | 皮膚 | 12 | 2.6% |
| sexual | 性功能 | 6 | 1.3% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| folate | 261 |
| folic acid | 196 |
| iron | 98 |
| vitamin B12 | 67 |
| EPA | 53 |
| vitamin D | 23 |
| calcium | 23 |
| zinc | 22 |
| vitamin B6 | 16 |
| vitamin A | 16 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| folate + iron | 55 |
| folic acid + iron | 50 |
| folate + vitamin B12 | 48 |
| folate + folic acid | 48 |
| EPA + folate | 34 |
| EPA + folic acid | 21 |
| folic acid + vitamin B12 | 19 |
| iron + vitamin B12 | 18 |
| folate + zinc | 18 |
| EPA + iron | 16 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 代謝 | 免疫調節 | 心血管 | 認知功能 | 抗衰老 |
|---|---|---|---|---|---|---|---|
| folate | 261 | 85 | 81 | 50 | 35 | 37 | 37 |
| folic acid | 196 | 87 | 42 | 33 | 23 | 24 | 15 |
| iron | 98 | 45 | 16 | 19 | 14 | 3 | 7 |
| vitamin B12 | 67 | 29 | 18 | 9 | 12 | 12 | 8 |
| EPA | 53 | 24 | 11 | 11 | 7 | 3 | 8 |
| vitamin D | 23 | 6 | 8 | 3 | 5 | 5 | 6 |
| calcium | 23 | 12 | 4 | 1 | 2 | 1 | - |
| zinc | 22 | 5 | 9 | 4 | 1 | 1 | 3 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 19 | 4.2% |
| Systematic Review | 10 | 2.2% |
| RCT | 9 | 2.0% |
| Clinical Trial | 2 | 0.4% |
| Observational | 1 | 0.2% |
| Review | 47 | 10.3% |
| Case Report | 16 | 3.5% |
| Other | 352 | 77.2% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
- 功效分類：cardiovascular, metabolic
- Nutritional Adequacy and Dietary Assessment Approaches in Institutionalised Older Adults Living in Long-Term Care Settings: A Systematic Review (2004-2024). — Nutrients, 2025-12-23
- 功效分類：metabolic, energy
- The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis. — Medicine, 2025-12-12
- 功效分類：other
- Global prevalences of erythropoiesis-associated micronutrient deficiencies (iron, folate, and vitamin B — Annals of medicine, 2025-12-01
- 功效分類：other
- Profile of neural tube defects in pediatric patients in Nigeria: A systematic review. — Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2026-03-01
- 功效分類：other
Level 2 證據（RCT）
- Impact evaluation of a population-based ‘Screen and Treat for Anaemia Reduction (STAR)’ strategy: a cluster randomised trial in rural Telangana, India. — BMJ global health, 2025-12-25
- 功效分類：other
- Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
- 功效分類：immune, metabolic
- Feasibility of a randomized clinical trial comparing 5-methyltetrahydrofolate and folic acid prenatal multivitamins in couples with recurrent pregnancy loss. — Nutrition research (New York, N.Y.), 2026-02-01
- 功效分類：metabolic
- Endothelial sensitivity to exercise-induced shear rate in older adults: effect of biological sex and acute folic acid consumption. — American journal of physiology. Heart and circulatory physiology, 2026-02-01
- 功效分類：other
- Efficacy of L-methylfolate and methylcobalamin in treating resistant hypertension associated with elevated serum homocysteine in hemodialysis patients. — BMC nephrology, 2026-01-24
- 功效分類：cardiovascular
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