葉酸文獻薈萃報告 — 2026 年 3 月

摘要

本月共收錄 葉酸 相關文獻 657 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）42 篇，RCT 11 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	42	6.4%
Level 2 (RCT)	11	1.7%
Level 3 (Clinical Trial)	2	0.3%
Level 4 (Observational)	1	0.2%
Level 5 (Review/Case Report/Other)	601	91.5%

功效分類統計

功效分類	中文	文獻數	佔比
other	其他	262	39.9%
metabolic	代謝	149	22.7%
immune	免疫調節	121	18.4%
cardiovascular	心血管	90	13.7%
anti_aging	抗衰老	74	11.3%
cognitive	認知功能	71	10.8%
musculoskeletal	肌肉骨骼	56	8.5%
digestive	消化	52	7.9%
energy	活力	37	5.6%
skin	皮膚	18	2.7%
sexual	性功能	12	1.8%

成分搭配統計

成分	文獻數
folate	365
folic acid	286
iron	155
vitamin B12	87
EPA	81
vitamin D	37
zinc	36
calcium	36
vitamin B6	22
vitamin A	19

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
folate + iron	86
folic acid + iron	76
folate + vitamin B12	66
folate + folic acid	65
EPA + folate	49
EPA + folic acid	37
folate + zinc	30
iron + vitamin B12	25
folic acid + vitamin B12	24
calcium + folate	24

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	其他	代謝	免疫調節	心血管	抗衰老	認知功能
folate	365	118	113	71	53	51	43
folic acid	286	123	54	53	39	26	34
iron	155	66	24	26	19	18	8
vitamin B12	87	35	27	12	19	9	15
EPA	81	33	19	17	13	13	6
vitamin D	37	8	14	4	8	9	7
zinc	36	6	12	4	4	5	2
calcium	36	14	8	4	6	-	2

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	27	4.1%
Systematic Review	15	2.3%
RCT	11	1.7%
Clinical Trial	2	0.3%
Observational	1	0.2%
Review	73	11.1%
Case Report	24	3.7%
Other	504	76.7%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. Systematic Review of Nutrients’ Impact on Cognition and School Performance in School-Aged Children in Sub-Saharan Africa. — Nutrition reviews, 2026-03-13
   • 功效分類：cardiovascular, cognitive
2. Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
   • 功效分類：cardiovascular, metabolic
3. Nutritional Adequacy and Dietary Assessment Approaches in Institutionalised Older Adults Living in Long-Term Care Settings: A Systematic Review (2004-2024). — Nutrients, 2025-12-23
   • 功效分類：metabolic, energy
4. The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis. — Medicine, 2025-12-12
   • 功效分類：other
5. Tumour-targeted fluorescence-guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research. — Clinical and translational medicine, 2026-03-01
   • 功效分類：anti_aging, digestive

Level 2 證據（RCT）

1. Impact evaluation of a population-based ‘Screen and Treat for Anaemia Reduction (STAR)’ strategy: a cluster randomised trial in rural Telangana, India. — BMJ global health, 2025-12-25
   • 功效分類：other
2. Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
   • 功效分類：immune, metabolic
3. Feasibility of a randomized clinical trial comparing 5-methyltetrahydrofolate and folic acid prenatal multivitamins in couples with recurrent pregnancy loss. — Nutrition research (New York, N.Y.), 2026-02-01
   • 功效分類：metabolic
4. Endothelial sensitivity to exercise-induced shear rate in older adults: effect of biological sex and acute folic acid consumption. — American journal of physiology. Heart and circulatory physiology, 2026-02-01
   • 功效分類：other
5. Maternal supplementation of vitamin B — BMJ paediatrics open, 2026-03-18
   • 功效分類：other

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