葉酸文獻薈萃報告 — 2026 年 4 月
摘要
本月共收錄 葉酸 相關文獻 884 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）52 篇，RCT 13 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 52 | 5.9% |
| Level 2 (RCT) | 13 | 1.5% |
| Level 3 (Clinical Trial) | 3 | 0.3% |
| Level 4 (Observational) | 3 | 0.3% |
| Level 5 (Review/Case Report/Other) | 813 | 92.0% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 330 | 37.3% |
| metabolic | 代謝 | 218 | 24.7% |
| immune | 免疫調節 | 182 | 20.6% |
| cardiovascular | 心血管 | 131 | 14.8% |
| anti_aging | 抗衰老 | 102 | 11.5% |
| cognitive | 認知功能 | 98 | 11.1% |
| musculoskeletal | 肌肉骨骼 | 75 | 8.5% |
| digestive | 消化 | 74 | 8.4% |
| energy | 活力 | 50 | 5.7% |
| skin | 皮膚 | 23 | 2.6% |
| sexual | 性功能 | 20 | 2.3% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| folate | 486 |
| folic acid | 375 |
| iron | 215 |
| vitamin B12 | 110 |
| EPA | 109 |
| vitamin D | 48 |
| zinc | 48 |
| calcium | 48 |
| vitamin A | 28 |
| vitamin B6 | 24 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| folate + iron | 118 |
| folic acid + iron | 102 |
| folate + vitamin B12 | 84 |
| folate + folic acid | 84 |
| EPA + folate | 64 |
| EPA + folic acid | 47 |
| folate + zinc | 38 |
| iron + vitamin B12 | 36 |
| folate + vitamin D | 32 |
| calcium + folate | 31 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 代謝 | 免疫調節 | 心血管 | 抗衰老 | 認知功能 |
|---|---|---|---|---|---|---|---|
| folate | 486 | 147 | 156 | 113 | 74 | 68 | 65 |
| folic acid | 375 | 156 | 76 | 70 | 58 | 33 | 39 |
| iron | 215 | 83 | 42 | 43 | 31 | 27 | 13 |
| vitamin B12 | 110 | 38 | 33 | 20 | 24 | 11 | 18 |
| EPA | 109 | 41 | 32 | 25 | 19 | 16 | 9 |
| vitamin D | 48 | 10 | 19 | 8 | 10 | 9 | 9 |
| zinc | 48 | 8 | 15 | 6 | 5 | 6 | 4 |
| calcium | 48 | 17 | 10 | 5 | 9 | 1 | 3 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 32 | 3.6% |
| Systematic Review | 20 | 2.3% |
| RCT | 13 | 1.5% |
| Clinical Trial | 3 | 0.3% |
| Observational | 3 | 0.3% |
| Review | 103 | 11.7% |
| Case Report | 34 | 3.8% |
| Other | 676 | 76.5% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Anaemia Among School-Going Adolescent Girls in India: A Systematic Review of Prevalence, Predictors, and Prevention Pathways. — Cureus, 2026-03-01
- 功效分類：other
- Systematic Review of Nutrients’ Impact on Cognition and School Performance in School-Aged Children in Sub-Saharan Africa. — Nutrition reviews, 2026-03-13
- 功效分類：cardiovascular, cognitive
- Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
- 功效分類：cardiovascular, metabolic
- Nutritional Adequacy and Dietary Assessment Approaches in Institutionalised Older Adults Living in Long-Term Care Settings: A Systematic Review (2004-2024). — Nutrients, 2025-12-23
- 功效分類：metabolic, energy
- The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis. — Medicine, 2025-12-12
- 功效分類：other
Level 2 證據（RCT）
- Impact evaluation of a population-based ‘Screen and Treat for Anaemia Reduction (STAR)’ strategy: a cluster randomised trial in rural Telangana, India. — BMJ global health, 2025-12-25
- 功效分類：other
- Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
- 功效分類：immune, metabolic
- Perception and acceptance of micronutrient-Fortified Bouillon among Non-Index Household Members: A longitudinal sub-study nested within a randomized trial in Northern Ghana. — PloS one, 2026-01-01
- 功效分類：sexual
- Feasibility of a randomized clinical trial comparing 5-methyltetrahydrofolate and folic acid prenatal multivitamins in couples with recurrent pregnancy loss. — Nutrition research (New York, N.Y.), 2026-02-01
- 功效分類：metabolic
- Endothelial sensitivity to exercise-induced shear rate in older adults: effect of biological sex and acute folic acid consumption. — American journal of physiology. Heart and circulatory physiology, 2026-02-01
- 功效分類：other
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