葉酸文獻薈萃報告 — 2026 年 6 月
摘要
本月共收錄 葉酸 相關文獻 1270 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）70 篇，RCT 16 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 70 | 5.5% |
| Level 2 (RCT) | 16 | 1.3% |
| Level 3 (Clinical Trial) | 5 | 0.4% |
| Level 4 (Observational) | 8 | 0.6% |
| Level 5 (Review/Case Report/Other) | 1171 | 92.2% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 447 | 35.2% |
| metabolic | 代謝 | 339 | 26.7% |
| immune | 免疫調節 | 275 | 21.7% |
| cardiovascular | 心血管 | 185 | 14.6% |
| cognitive | 認知功能 | 140 | 11.0% |
| anti_aging | 抗衰老 | 134 | 10.6% |
| digestive | 消化 | 116 | 9.1% |
| musculoskeletal | 肌肉骨骼 | 105 | 8.3% |
| energy | 活力 | 78 | 6.1% |
| skin | 皮膚 | 35 | 2.8% |
| sexual | 性功能 | 31 | 2.4% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| folate | 712 |
| folic acid | 527 |
| iron | 300 |
| vitamin B12 | 164 |
| EPA | 145 |
| vitamin D | 91 |
| zinc | 77 |
| calcium | 65 |
| vitamin A | 42 |
| vitamin C | 40 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| folate + iron | 170 |
| folic acid + iron | 141 |
| folate + vitamin B12 | 127 |
| folate + folic acid | 126 |
| EPA + folate | 79 |
| EPA + folic acid | 67 |
| folate + vitamin D | 65 |
| folate + zinc | 58 |
| iron + vitamin B12 | 56 |
| folic acid + vitamin B12 | 48 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 代謝 | 免疫調節 | 心血管 | 認知功能 | 抗衰老 |
|---|---|---|---|---|---|---|---|
| folate | 712 | 208 | 247 | 161 | 107 | 92 | 88 |
| folic acid | 527 | 212 | 111 | 107 | 78 | 52 | 41 |
| iron | 300 | 110 | 71 | 66 | 40 | 16 | 33 |
| vitamin B12 | 164 | 54 | 53 | 29 | 29 | 30 | 17 |
| EPA | 145 | 51 | 40 | 38 | 23 | 12 | 18 |
| vitamin D | 91 | 23 | 34 | 18 | 16 | 14 | 13 |
| zinc | 77 | 16 | 23 | 13 | 7 | 8 | 10 |
| calcium | 65 | 19 | 14 | 8 | 12 | 7 | 4 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 41 | 3.2% |
| Systematic Review | 29 | 2.3% |
| RCT | 16 | 1.3% |
| Clinical Trial | 5 | 0.4% |
| Observational | 8 | 0.6% |
| Review | 145 | 11.4% |
| Case Report | 47 | 3.7% |
| Other | 979 | 77.1% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Anaemia Among School-Going Adolescent Girls in India: A Systematic Review of Prevalence, Predictors, and Prevention Pathways. — Cureus, 2026-03-01
- 功效分類：other
- Safeguarding diet quality in a changing climate: a scoping review. — Frontiers in nutrition, 2026-01-01
- 功效分類：energy
- Systematic Review of Nutrients’ Impact on Cognition and School Performance in School-Aged Children in Sub-Saharan Africa. — Nutrition reviews, 2026-03-13
- 功效分類：cardiovascular, cognitive
- Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
- 功效分類：cardiovascular, metabolic
- Effects of excess folic acid and high blood folate during preconception and pregnancy: systematic review. — Reproductive biomedicine online, 2025-09-12
- 功效分類：metabolic
Level 2 證據（RCT）
- A prospective, randomized, double-blind, placebo-controlled, multicenter study of thiamin plus folic acid in the treatment of cognitive impairment in patients undergoing maintenance hemodialysis. — Renal failure, 2026-12-01
- 功效分類：cognitive
- Impact evaluation of a population-based ‘Screen and Treat for Anaemia Reduction (STAR)’ strategy: a cluster randomised trial in rural Telangana, India. — BMJ global health, 2025-12-25
- 功效分類：other
- Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
- 功效分類：immune, metabolic
- Comparison of mediterranean and healthy eating guideline interventions on the dietary inflammatory index in rheumatoid arthritis: results from a dietary randomised controlled intervention trial. — European journal of nutrition, 2026-05-26
- 功效分類：immune, musculoskeletal, energy
- Perception and acceptance of micronutrient-Fortified Bouillon among Non-Index Household Members: A longitudinal sub-study nested within a randomized trial in Northern Ghana. — PloS one, 2026-01-01
- 功效分類：sexual
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