葡萄糖胺文獻薈萃報告 — 2026 年 2 月

摘要

本月共收錄 葡萄糖胺 相關文獻 616 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）34 篇，RCT 23 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	34	5.5%
Level 2 (RCT)	23	3.7%
Level 3 (Clinical Trial)	2	0.3%
Level 4 (Observational)	2	0.3%
Level 5 (Review/Case Report/Other)	555	90.1%

功效分類統計

功效分類	中文	文獻數	佔比
musculoskeletal	肌肉骨骼	488	79.2%
immune	免疫調節	216	35.1%
skin	皮膚	132	21.4%
other	其他	63	10.2%
anti_aging	抗衰老	62	10.1%
metabolic	代謝	61	9.9%
cardiovascular	心血管	52	8.4%
digestive	消化	28	4.5%
cognitive	認知功能	15	2.4%
energy	活力	9	1.5%

成分搭配統計

成分	文獻數
chondroitin	404
glucosamine	248
EPA	170
collagen	115
hyaluronic acid	88
iron	65
stem cell	62
NAC	32
fiber	16
calcium	15

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
EPA + chondroitin	139
chondroitin + collagen	92
chondroitin + glucosamine	91
chondroitin + hyaluronic acid	74
chondroitin + stem cell	55
chondroitin + iron	52
EPA + collagen	40
collagen + glucosamine	39
EPA + glucosamine	38
EPA + stem cell	38

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	肌肉骨骼	免疫調節	皮膚	抗衰老	其他	代謝
chondroitin	404	308	138	103	38	47	35
glucosamine	248	232	105	45	28	4	30
EPA	170	123	56	44	20	24	11
collagen	115	90	33	115	17	-	8
hyaluronic acid	88	68	30	25	6	9	4
iron	65	48	27	15	11	7	5
stem cell	62	41	15	24	3	11	3
NAC	32	24	13	8	4	4	4

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	19	3.1%
Systematic Review	15	2.4%
RCT	23	3.7%
Clinical Trial	2	0.3%
Observational	2	0.3%
Review	69	11.2%
Case Report	9	1.5%
Other	477	77.4%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: A protocol for systematic review and meta-analysis. — Medicine, 2023-02-22
   • 功效分類：immune, musculoskeletal, skin
2. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review. — Nutrients, 2025-06-24
   • 功效分類：anti_aging, musculoskeletal
3. Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: a systematic review and meta-analysis. — European journal of translational myology, 2023-11-23
   • 功效分類：musculoskeletal
4. [SYSADOA place in degenerative-dystrophic joints diseases treatment of neurological practice from the standpoint of evidence-based medicine]. — Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022-01-01
   • 功效分類：anti_aging, cognitive, musculoskeletal
5. Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis. — Archives of orthopaedic and trauma surgery, 2023-01-01
   • 功效分類：musculoskeletal

Level 2 證據（RCT）

1. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
   • 功效分類：musculoskeletal, skin
2. Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study. — Arthritis research & therapy, 2021-06-04
   • 功效分類：cardiovascular, immune, metabolic, musculoskeletal
3. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial. — Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2021-08-01
   • 功效分類：musculoskeletal
4. Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health. — Nutrients, 2022-08-05
   • 功效分類：musculoskeletal
5. Cost-Effectiveness Analysis of Pharmaceutical-Grade Chondroitin Sulfate for Knee Osteoarthritis Based on Individual Patient Data from a Randomized Clinical Trial. — Advances in therapy, 2025-01-01
   • 功效分類：musculoskeletal