葡萄糖胺文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 葡萄糖胺 相關文獻 620 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）34 篇，RCT 23 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 34 | 5.5% |
| Level 2 (RCT) | 23 | 3.7% |
| Level 3 (Clinical Trial) | 2 | 0.3% |
| Level 4 (Observational) | 2 | 0.3% |
| Level 5 (Review/Case Report/Other) | 559 | 90.2% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| musculoskeletal | 肌肉骨骼 | 492 | 79.4% |
| immune | 免疫調節 | 219 | 35.3% |
| skin | 皮膚 | 133 | 21.5% |
| other | 其他 | 63 | 10.2% |
| anti_aging | 抗衰老 | 62 | 10.0% |
| metabolic | 代謝 | 61 | 9.8% |
| cardiovascular | 心血管 | 54 | 8.7% |
| digestive | 消化 | 29 | 4.7% |
| cognitive | 認知功能 | 15 | 2.4% |
| energy | 活力 | 10 | 1.6% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| chondroitin | 406 |
| glucosamine | 249 |
| EPA | 171 |
| collagen | 115 |
| hyaluronic acid | 88 |
| iron | 67 |
| stem cell | 62 |
| NAC | 32 |
| fiber | 16 |
| calcium | 15 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| EPA + chondroitin | 139 |
| chondroitin + collagen | 92 |
| chondroitin + glucosamine | 91 |
| chondroitin + hyaluronic acid | 74 |
| chondroitin + stem cell | 55 |
| chondroitin + iron | 54 |
| EPA + collagen | 40 |
| collagen + glucosamine | 39 |
| EPA + glucosamine | 39 |
| EPA + stem cell | 38 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 肌肉骨骼 | 免疫調節 | 皮膚 | 抗衰老 | 其他 | 代謝 |
|---|---|---|---|---|---|---|---|
| chondroitin | 406 | 310 | 139 | 103 | 38 | 47 | 35 |
| glucosamine | 249 | 233 | 106 | 46 | 28 | 4 | 30 |
| EPA | 171 | 124 | 57 | 45 | 20 | 24 | 11 |
| collagen | 115 | 90 | 33 | 115 | 17 | - | 8 |
| hyaluronic acid | 88 | 68 | 30 | 25 | 6 | 9 | 4 |
| iron | 67 | 50 | 28 | 15 | 11 | 7 | 5 |
| stem cell | 62 | 41 | 15 | 24 | 3 | 11 | 3 |
| NAC | 32 | 24 | 13 | 8 | 4 | 4 | 4 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 19 | 3.1% |
| Systematic Review | 15 | 2.4% |
| RCT | 23 | 3.7% |
| Clinical Trial | 2 | 0.3% |
| Observational | 2 | 0.3% |
| Review | 69 | 11.1% |
| Case Report | 9 | 1.5% |
| Other | 481 | 77.6% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: A protocol for systematic review and meta-analysis. — Medicine, 2023-02-22
- 功效分類：immune, musculoskeletal, skin
- The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review. — Nutrients, 2025-06-24
- 功效分類：anti_aging, musculoskeletal
- Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: a systematic review and meta-analysis. — European journal of translational myology, 2023-11-23
- 功效分類：musculoskeletal
- [SYSADOA place in degenerative-dystrophic joints diseases treatment of neurological practice from the standpoint of evidence-based medicine]. — Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022-01-01
- 功效分類：anti_aging, cognitive, musculoskeletal
- Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis. — Archives of orthopaedic and trauma surgery, 2023-01-01
- 功效分類：musculoskeletal
Level 2 證據（RCT）
- Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
- 功效分類：musculoskeletal, skin
- Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study. — Arthritis research & therapy, 2021-06-04
- 功效分類：cardiovascular, immune, metabolic, musculoskeletal
- Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial. — Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2021-08-01
- 功效分類：musculoskeletal
- Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health. — Nutrients, 2022-08-05
- 功效分類：musculoskeletal
- Cost-Effectiveness Analysis of Pharmaceutical-Grade Chondroitin Sulfate for Knee Osteoarthritis Based on Individual Patient Data from a Randomized Clinical Trial. — Advances in therapy, 2025-01-01
- 功效分類：musculoskeletal
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