葡萄糖胺文獻薈萃報告 — 2026 年 6 月

摘要

本月共收錄 葡萄糖胺 相關文獻 657 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）34 篇，RCT 24 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	34	5.2%
Level 2 (RCT)	24	3.7%
Level 3 (Clinical Trial)	2	0.3%
Level 4 (Observational)	2	0.3%
Level 5 (Review/Case Report/Other)	595	90.6%

功效分類統計

功效分類	中文	文獻數	佔比
musculoskeletal	肌肉骨骼	519	79.0%
immune	免疫調節	234	35.6%
skin	皮膚	143	21.8%
anti_aging	抗衰老	70	10.7%
other	其他	67	10.2%
metabolic	代謝	66	10.0%
cardiovascular	心血管	58	8.8%
digestive	消化	32	4.9%
cognitive	認知功能	16	2.4%
energy	活力	10	1.5%

成分搭配統計

成分	文獻數
chondroitin	431
glucosamine	256
EPA	177
collagen	124
hyaluronic acid	92
iron	72
stem cell	64
NAC	34
fiber	17
calcium	15

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
EPA + chondroitin	144
chondroitin + collagen	99
chondroitin + glucosamine	93
chondroitin + hyaluronic acid	77
chondroitin + iron	57
chondroitin + stem cell	56
EPA + collagen	42
collagen + glucosamine	41
EPA + glucosamine	39
EPA + stem cell	39

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	肌肉骨骼	免疫調節	皮膚	抗衰老	其他	代謝
chondroitin	431	329	148	111	43	49	38
glucosamine	256	239	110	48	30	4	32
EPA	177	130	60	47	21	24	11
collagen	124	96	35	124	19	-	10
hyaluronic acid	92	71	32	26	6	9	4
iron	72	53	31	16	11	8	5
stem cell	64	42	16	25	3	11	3
NAC	34	26	15	9	4	4	5

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	19	2.9%
Systematic Review	15	2.3%
RCT	24	3.7%
Clinical Trial	2	0.3%
Observational	2	0.3%
Review	73	11.1%
Case Report	10	1.5%
Other	512	77.9%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: A protocol for systematic review and meta-analysis. — Medicine, 2023-02-22
   • 功效分類：immune, musculoskeletal, skin
2. The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review. — Nutrients, 2025-06-24
   • 功效分類：anti_aging, musculoskeletal
3. Effects of adding glucosamine or glucosamine combined with chondroitin to exercise on pain and physical function in adults with knee osteoarthritis: a systematic review and meta-analysis. — European journal of translational myology, 2023-11-23
   • 功效分類：musculoskeletal
4. [SYSADOA place in degenerative-dystrophic joints diseases treatment of neurological practice from the standpoint of evidence-based medicine]. — Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022-01-01
   • 功效分類：anti_aging, cognitive, musculoskeletal
5. Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis. — Archives of orthopaedic and trauma surgery, 2023-01-01
   • 功效分類：musculoskeletal

Level 2 證據（RCT）

1. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. — Nutrition journal, 2023-03-15
   • 功效分類：musculoskeletal, skin
2. Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study. — Arthritis research & therapy, 2021-06-04
   • 功效分類：cardiovascular, immune, metabolic, musculoskeletal
3. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial. — Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2021-08-01
   • 功效分類：musculoskeletal
4. [ — Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026-05-20
   • 功效分類：other
5. Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health. — Nutrients, 2022-08-05
   • 功效分類：musculoskeletal

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