乳酸桿菌文獻薈萃報告 — 2026 年 6 月

摘要

本月共收錄 乳酸桿菌 相關文獻 2057 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）126 篇，RCT 18 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	126	6.1%
Level 2 (RCT)	18	0.9%
Level 3 (Clinical Trial)	12	0.6%
Level 4 (Observational)	1	0.0%
Level 5 (Review/Case Report/Other)	1900	92.4%

功效分類統計

功效分類	中文	文獻數	佔比
digestive	消化	1720	83.6%
immune	免疫調節	880	42.8%
metabolic	代謝	498	24.2%
cardiovascular	心血管	228	11.1%
cognitive	認知功能	221	10.7%
other	其他	219	10.6%
anti_aging	抗衰老	145	7.0%
musculoskeletal	肌肉骨骼	118	5.7%
skin	皮膚	84	4.1%
energy	活力	60	2.9%
sexual	性功能	30	1.5%

成分搭配統計

成分	文獻數
probiotics	856
iron	285
EPA	274
prebiotics	177
fiber	77
NAC	45
calcium	29
vitamin D	19
collagen	19
curcumin	19

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
prebiotics + probiotics	167
iron + probiotics	145
EPA + probiotics	124
EPA + iron	37
fiber + probiotics	36
iron + prebiotics	32
NAC + probiotics	23
EPA + prebiotics	21
omega-3 + probiotics	16
probiotics + vitamin D	16

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	消化	免疫調節	代謝	心血管	認知功能	抗衰老
probiotics	856	856	469	211	101	119	86
iron	285	247	156	62	26	24	17
EPA	274	246	146	98	61	16	32
prebiotics	177	177	135	57	28	48	23
fiber	77	70	36	31	23	5	7
NAC	45	42	24	9	5	5	2
calcium	29	21	14	8	4	2	3
vitamin D	19	18	10	7	2	-	1

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	57	2.8%
Systematic Review	69	3.4%
RCT	18	0.9%
Clinical Trial	12	0.6%
Observational	1	0.0%
Review	457	22.2%
Case Report	5	0.2%
Other	1438	69.9%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. [Therapeutic Strategies in the Management of Functional Constipation in Children: A narrative review]. — Andes pediatrica : revista Chilena de pediatria, 2025-12-01
   • 功效分類：digestive
2. The association between gut microbiota and cognitive decline: A systematic review of the literature. — Nutrition research (New York, N.Y.), 2026-01-12
   • 功效分類：cognitive, immune, digestive
3. An Umbrella Review on the Prevention of Skin Diseases: Do Specific Nutrients Play a Protective Role? — Preventive nutrition and food science, 2026-02-01
   • 功效分類：skin
4. The role of short-chain fatty acids in spinal cord injury: A systematic review of human and animal evidence. — The journal of spinal cord medicine, 2026-02-19
   • 功效分類：immune, digestive
5. Probiotics for Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis With Trial Sequential Analysis. — Journal of gastroenterology and hepatology, 2026-03-12
   • 功效分類：digestive

Level 2 證據（RCT）

1. Bifidobacterium longum BB536 is associated with improvements in gastrointestinal symptoms and odor-related metabolites in microbiota-defined subgroups of male athletes consuming a high-protein diet: exploratory randomized double‑blind placebo‑controlled trial. — Journal of the International Society of Sports Nutrition, 2026-12-31
   • 功效分類：digestive
2. Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial. — Frontiers in endocrinology, 2026-01-01
   • 功效分類：cardiovascular, metabolic, digestive
3. Identification and evaluation of gut microbiome as non-invasive biomarkers for early lung adenocarcinoma from a multi-center study. — Frontiers in cellular and infection microbiology, 2026-01-01
   • 功效分類：digestive
4. Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation. — Journal of mother and child, 2026-01-01
   • 功效分類：immune, digestive
5. Acceptability and efficacy of low-dose zinc with or without probiotics in acute watery diarrhoea-a prospective comparative study. — Journal of tropical pediatrics, 2026-04-11
   • 功效分類：digestive

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