NMN文獻薈萃報告 — 2026 年 3 月

摘要

本月共收錄 NMN 相關文獻 986 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）12 篇，RCT 9 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	12	1.2%
Level 2 (RCT)	9	0.9%
Level 3 (Clinical Trial)	0	0.0%
Level 4 (Observational)	1	0.1%
Level 5 (Review/Case Report/Other)	964	97.8%

功效分類統計

功效分類	中文	文獻數	佔比
other	其他	362	36.7%
metabolic	代謝	248	25.2%
anti_aging	抗衰老	226	22.9%
immune	免疫調節	152	15.4%
cardiovascular	心血管	121	12.3%
cognitive	認知功能	120	12.2%
energy	活力	89	9.0%
musculoskeletal	肌肉骨骼	80	8.1%
digestive	消化	54	5.5%
skin	皮膚	35	3.5%
sexual	性功能	26	2.6%

成分搭配統計

成分	文獻數
nicotinamide mononucleotide	484
NMN	456
NAD+	103
EPA	95
iron	55
stem cell	35
NAD precursor	35
fiber	19
collagen	13
NAC	12

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
NMN + nicotinamide mononucleotide	357
NAD+ + nicotinamide mononucleotide	68
NAD+ + NMN	63
EPA + NMN	60
EPA + nicotinamide mononucleotide	53
iron + nicotinamide mononucleotide	35
NMN + iron	33
nicotinamide mononucleotide + stem cell	20
NMN + stem cell	17
NAD precursor + NMN	14

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	代謝	抗衰老	其他	免疫調節	認知功能	心血管
nicotinamide mononucleotide	484	140	147	131	93	66	60
NMN	456	128	116	147	85	64	54
NAD+	103	52	34	15	29	21	18
EPA	95	36	21	31	22	11	14
iron	55	21	15	9	18	10	12
stem cell	35	7	18	3	8	7	6
NAD precursor	35	17	10	6	3	10	3
fiber	19	2	2	10	2	1	2

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	7	0.7%
Systematic Review	5	0.5%
RCT	9	0.9%
Clinical Trial	0	0.0%
Observational	1	0.1%
Review	16	1.6%
Case Report	3	0.3%
Other	945	95.8%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis. — Frontiers in public health,
   • 功效分類：anti_aging
2. NAD⁺ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence. — Ageing research reviews,
   • 功效分類：anti_aging, immune
3. Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. — Critical reviews in food science and nutrition,
   • 功效分類：cardiovascular, metabolic
4. Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials. — Current pharmaceutical biotechnology,
   • 功效分類：anti_aging, musculoskeletal
5. Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials. — Cureus,
   • 功效分類：musculoskeletal, energy

Level 2 證據（RCT）

1. NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults. — The Journal of nutrition, 2021-10-01
   • 功效分類：anti_aging, metabolic, musculoskeletal
2. Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease. — Alzheimer’s research & therapy, 2025-03-11
   • 功效分類：cognitive
3. Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}. — BMC cancer, 2022-07-19
   • 功效分類：cardiovascular, metabolic, musculoskeletal, energy
4. Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise. — Journal of the International Society of Sports Nutrition, 2026-12-31
   • 功效分類：immune, musculoskeletal
5. Protective effect of D-(-)-quinic acid as food supplement in modulating AMP-activated protein kinase signalling pathway activation in HFD induced obesity. — Human & experimental toxicology, 2022-01-01
   • 功效分類：cardiovascular, immune, metabolic, digestive

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