NMN文獻薈萃報告 — 2026 年 4 月
摘要
本月共收錄 NMN 相關文獻 1000 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）12 篇，RCT 9 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 12 | 1.2% |
| Level 2 (RCT) | 9 | 0.9% |
| Level 3 (Clinical Trial) | 0 | 0.0% |
| Level 4 (Observational) | 1 | 0.1% |
| Level 5 (Review/Case Report/Other) | 978 | 97.8% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 365 | 36.5% |
| metabolic | 代謝 | 256 | 25.6% |
| anti_aging | 抗衰老 | 228 | 22.8% |
| immune | 免疫調節 | 157 | 15.7% |
| cardiovascular | 心血管 | 122 | 12.2% |
| cognitive | 認知功能 | 122 | 12.2% |
| energy | 活力 | 90 | 9.0% |
| musculoskeletal | 肌肉骨骼 | 83 | 8.3% |
| digestive | 消化 | 54 | 5.4% |
| skin | 皮膚 | 36 | 3.6% |
| sexual | 性功能 | 27 | 2.7% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| nicotinamide mononucleotide | 493 |
| NMN | 464 |
| NAD+ | 103 |
| EPA | 97 |
| iron | 57 |
| stem cell | 36 |
| NAD precursor | 35 |
| fiber | 19 |
| collagen | 14 |
| NAC | 12 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| NMN + nicotinamide mononucleotide | 365 |
| NAD+ + nicotinamide mononucleotide | 68 |
| NAD+ + NMN | 63 |
| EPA + NMN | 62 |
| EPA + nicotinamide mononucleotide | 55 |
| iron + nicotinamide mononucleotide | 37 |
| NMN + iron | 35 |
| nicotinamide mononucleotide + stem cell | 21 |
| NMN + stem cell | 18 |
| NAD precursor + NMN | 14 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 代謝 | 抗衰老 | 其他 | 免疫調節 | 認知功能 | 心血管 |
|---|---|---|---|---|---|---|---|
| nicotinamide mononucleotide | 493 | 145 | 149 | 133 | 96 | 67 | 60 |
| NMN | 464 | 133 | 118 | 148 | 88 | 65 | 54 |
| NAD+ | 103 | 52 | 34 | 15 | 29 | 21 | 18 |
| EPA | 97 | 38 | 22 | 31 | 23 | 12 | 14 |
| iron | 57 | 22 | 15 | 9 | 19 | 10 | 12 |
| stem cell | 36 | 8 | 18 | 3 | 8 | 7 | 6 |
| NAD precursor | 35 | 17 | 10 | 6 | 3 | 10 | 3 |
| fiber | 19 | 2 | 2 | 10 | 2 | 1 | 2 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 7 | 0.7% |
| Systematic Review | 5 | 0.5% |
| RCT | 9 | 0.9% |
| Clinical Trial | 0 | 0.0% |
| Observational | 1 | 0.1% |
| Review | 17 | 1.7% |
| Case Report | 3 | 0.3% |
| Other | 958 | 95.8% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis. — Frontiers in public health,
- 功效分類：anti_aging
- NAD⁺ supplementation for anti-aging and wellness: a PRISMA-guided systematic review of preclinical and clinical evidence. — Ageing research reviews,
- 功效分類：anti_aging, immune
- Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. — Critical reviews in food science and nutrition,
- 功效分類：cardiovascular, metabolic
- Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials. — Current pharmaceutical biotechnology,
- 功效分類：anti_aging, musculoskeletal
- Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials. — Cureus,
- 功效分類：musculoskeletal, energy
Level 2 證據（RCT）
- NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults. — The Journal of nutrition, 2021-10-01
- 功效分類：anti_aging, metabolic, musculoskeletal
- Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer’s disease. — Alzheimer’s research & therapy, 2025-03-11
- 功效分類：cognitive
- Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}. — BMC cancer, 2022-07-19
- 功效分類：cardiovascular, metabolic, musculoskeletal, energy
- Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise. — Journal of the International Society of Sports Nutrition, 2026-12-31
- 功效分類：immune, musculoskeletal
- Protective effect of D-(-)-quinic acid as food supplement in modulating AMP-activated protein kinase signalling pathway activation in HFD induced obesity. — Human & experimental toxicology, 2022-01-01
- 功效分類：cardiovascular, immune, metabolic, digestive
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