Vitamin B12文獻薈萃報告 — 2026 年 2 月
摘要
本月共收錄 Vitamin B12 相關文獻 461 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）31 篇，RCT 4 篇。
證據等級分布
| 證據等級 | 文獻數 | 佔比 |
|---|---|---|
| Level 1 (Meta-Analysis/Systematic Review) | 31 | 6.7% |
| Level 2 (RCT) | 4 | 0.9% |
| Level 3 (Clinical Trial) | 2 | 0.4% |
| Level 4 (Observational) | 10 | 2.2% |
| Level 5 (Review/Case Report/Other) | 414 | 89.8% |
功效分類統計
| 功效分類 | 中文 | 文獻數 | 佔比 |
|---|---|---|---|
| other | 其他 | 147 | 31.9% |
| metabolic | 代謝 | 133 | 28.9% |
| cognitive | 認知功能 | 92 | 20.0% |
| immune | 免疫調節 | 79 | 17.1% |
| cardiovascular | 心血管 | 59 | 12.8% |
| anti_aging | 抗衰老 | 53 | 11.5% |
| digestive | 消化 | 44 | 9.5% |
| energy | 活力 | 43 | 9.3% |
| musculoskeletal | 肌肉骨骼 | 41 | 8.9% |
| skin | 皮膚 | 16 | 3.5% |
| sexual | 性功能 | 8 | 1.7% |
成分搭配統計
| 成分 | 文獻數 |
|---|---|
| vitamin B12 | 382 |
| folate | 118 |
| iron | 109 |
| vitamin D | 62 |
| EPA | 51 |
| folic acid | 51 |
| zinc | 46 |
| calcium | 45 |
| vitamin B6 | 30 |
| vitamin A | 28 |
成分組合分析
以下列出最常被共同研究的成分組合：
| 成分組合 | 共同出現文獻數 |
|---|---|
| folate + vitamin B12 | 110 |
| iron + vitamin B12 | 100 |
| vitamin B12 + vitamin D | 60 |
| EPA + vitamin B12 | 48 |
| folic acid + vitamin B12 | 48 |
| folate + iron | 47 |
| vitamin B12 + zinc | 44 |
| calcium + vitamin B12 | 43 |
| iron + zinc | 38 |
| calcium + iron | 30 |
成分功效分析
以下列出主要成分在各功效領域的研究文獻數：
| 成分 | 總文獻 | 其他 | 代謝 | 認知功能 | 免疫調節 | 心血管 | 抗衰老 |
|---|---|---|---|---|---|---|---|
| vitamin B12 | 382 | 116 | 115 | 82 | 67 | 54 | 52 |
| folate | 118 | 43 | 32 | 24 | 20 | 21 | 13 |
| iron | 109 | 46 | 26 | 15 | 17 | 10 | 9 |
| vitamin D | 62 | 17 | 22 | 14 | 11 | 15 | 6 |
| EPA | 51 | 15 | 16 | 9 | 14 | 5 | 6 |
| folic acid | 51 | 26 | 14 | 5 | 8 | 9 | 3 |
| zinc | 46 | 15 | 11 | 6 | 7 | 6 | 1 |
| calcium | 45 | 13 | 15 | 7 | 10 | 9 | 3 |
研究類型分布
| 研究類型 | 文獻數 | 佔比 |
|---|---|---|
| Meta-Analysis | 20 | 4.3% |
| Systematic Review | 11 | 2.4% |
| RCT | 4 | 0.9% |
| Clinical Trial | 2 | 0.4% |
| Observational | 10 | 2.2% |
| Review | 52 | 11.3% |
| Case Report | 48 | 10.4% |
| Other | 314 | 68.1% |
近期重要文獻
Level 1 證據（Meta-Analysis / Systematic Review）
- Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
- 功效分類：cardiovascular, metabolic
- The Nutritional Challenges Following Revisional Bariatric Surgery After Sleeve Gastrectomy: A Systematic Review and Meta Analysis. — Obesity surgery, 2025-12-01
- 功效分類：metabolic
- Invisible Links: Associations Between Micronutrient Deficiencies and Postpartum Depression-A Systematic Review. — Life (Basel, Switzerland), 2025-10-08
- 功效分類：other
- The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis. — Medicine, 2025-12-12
- 功效分類：other
- THE SIGNIFICANCE OF INTERLEUKIN-22 AND HOMOCYSTEINE IN THE PROGNOSIS OF PREMATURE ANTEPARTUM RUPTURE OF MEMBRANES IN PREGNANT WOMEN. — Georgian medical news, 2025-12-01
- 功效分類：immune, sexual
Level 2 證據（RCT）
- Plasma proteomic profiles reveal immune modulation by immunonutrition in GI cancer. — Nutrition (Burbank, Los Angeles County, Calif.), 2026-03-01
- 功效分類：immune, digestive
- Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
- 功效分類：immune, metabolic
- Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a 3-year prospective analysis of the DO-HEALTH trial. — The American journal of clinical nutrition, 2026-02-01
- 功效分類：anti_aging, cognitive
- Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial. — JAMA network open, 2025-09-02
- 功效分類：anti_aging, sexual
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