Vitamin B12文獻薈萃報告 — 2026 年 4 月

摘要

本月共收錄 Vitamin B12 相關文獻 514 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）34 篇，RCT 4 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	34	6.6%
Level 2 (RCT)	4	0.8%
Level 3 (Clinical Trial)	2	0.4%
Level 4 (Observational)	10	1.9%
Level 5 (Review/Case Report/Other)	464	90.3%

功效分類統計

功效分類	中文	文獻數	佔比
other	其他	158	30.7%
metabolic	代謝	151	29.4%
cognitive	認知功能	105	20.4%
immune	免疫調節	89	17.3%
cardiovascular	心血管	72	14.0%
anti_aging	抗衰老	59	11.5%
digestive	消化	49	9.5%
energy	活力	46	8.9%
musculoskeletal	肌肉骨骼	45	8.8%
skin	皮膚	19	3.7%
sexual	性功能	8	1.6%

成分搭配統計

成分	文獻數
vitamin B12	431
folate	137
iron	119
vitamin D	73
EPA	58
folic acid	56
zinc	51
calcium	50
vitamin B6	36
magnesium	30

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
folate + vitamin B12	128
iron + vitamin B12	110
vitamin B12 + vitamin D	70
folate + iron	54
EPA + vitamin B12	54
folic acid + vitamin B12	53
vitamin B12 + zinc	49
calcium + vitamin B12	48
iron + zinc	41
vitamin B12 + vitamin B6	36

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	其他	代謝	認知功能	免疫調節	心血管	抗衰老
vitamin B12	431	125	132	95	77	67	57
folate	137	48	40	26	23	27	15
iron	119	50	28	17	18	12	10
vitamin D	73	20	27	17	13	17	9
EPA	58	18	18	11	16	6	7
folic acid	56	27	16	7	9	11	4
zinc	51	16	13	8	8	8	2
calcium	50	14	17	8	11	10	3

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	21	4.1%
Systematic Review	13	2.5%
RCT	4	0.8%
Clinical Trial	2	0.4%
Observational	10	1.9%
Review	57	11.1%
Case Report	52	10.1%
Other	355	69.1%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. Systematic Review of Nutrients’ Impact on Cognition and School Performance in School-Aged Children in Sub-Saharan Africa. — Nutrition reviews, 2026-03-13
   • 功效分類：cardiovascular, cognitive
2. Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. — Annals of medicine, 2026-12-01
   • 功效分類：cardiovascular, metabolic
3. The Nutritional Challenges Following Revisional Bariatric Surgery After Sleeve Gastrectomy: A Systematic Review and Meta Analysis. — Obesity surgery, 2025-12-01
   • 功效分類：metabolic
4. Invisible Links: Associations Between Micronutrient Deficiencies and Postpartum Depression-A Systematic Review. — Life (Basel, Switzerland), 2025-10-08
   • 功效分類：other
5. The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis. — Medicine, 2025-12-12
   • 功效分類：other

Level 2 證據（RCT）

1. Plasma proteomic profiles reveal immune modulation by immunonutrition in GI cancer. — Nutrition (Burbank, Los Angeles County, Calif.), 2026-03-01
   • 功效分類：immune, digestive
2. Nutritional status-dependent DNA methylation modifications on adipose tissue in systemic lupus erythematosus women following folic acid and vitamin B12 supplementation: a randomized double-blind placebo-controlled trial. — Clinical epigenetics, 2026-01-03
   • 功效分類：immune, metabolic
3. Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a 3-year prospective analysis of the DO-HEALTH trial. — The American journal of clinical nutrition, 2026-02-01
   • 功效分類：anti_aging, cognitive
4. Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care: The SUMMER Randomized Clinical Trial. — JAMA network open, 2025-09-02
   • 功效分類：anti_aging, sexual

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