Vitamin D文獻薈萃報告 — 2026 年 4 月

摘要

本月共收錄 Vitamin D 相關文獻 766 篇，其中 Level 1 證據（Meta-Analysis/Systematic Review）53 篇，RCT 5 篇。

證據等級分布

證據等級	文獻數	佔比
Level 1 (Meta-Analysis/Systematic Review)	53	6.9%
Level 2 (RCT)	5	0.7%
Level 3 (Clinical Trial)	1	0.1%
Level 4 (Observational)	13	1.7%
Level 5 (Review/Case Report/Other)	694	90.6%

功效分類統計

功效分類	中文	文獻數	佔比
musculoskeletal	肌肉骨骼	262	34.2%
metabolic	代謝	236	30.8%
immune	免疫調節	225	29.4%
other	其他	183	23.9%
cardiovascular	心血管	127	16.6%
anti_aging	抗衰老	96	12.5%
energy	活力	69	9.0%
cognitive	認知功能	60	7.8%
digestive	消化	49	6.4%
sexual	性功能	35	4.6%
skin	皮膚	35	4.6%

成分搭配統計

成分	文獻數
vitamin D	705
calcium	189
EPA	78
iron	74
zinc	37
magnesium	28
NAC	24
omega-3	20
selenium	17
vitamin E	16

成分組合分析

以下列出最常被共同研究的成分組合：

成分組合	共同出現文獻數
calcium + vitamin D	183
EPA + vitamin D	72
iron + vitamin D	69
vitamin D + zinc	33
magnesium + vitamin D	26
calcium + iron	21
NAC + vitamin D	21
EPA + calcium	20
calcium + magnesium	19
omega-3 + vitamin D	19

成分功效分析

以下列出主要成分在各功效領域的研究文獻數：

成分	總文獻	肌肉骨骼	代謝	免疫調節	其他	心血管	抗衰老
vitamin D	705	245	223	215	163	120	92
calcium	189	105	54	33	46	23	30
EPA	78	27	32	31	14	15	12
iron	74	17	21	32	22	11	9
zinc	37	8	14	18	2	8	5
magnesium	28	8	6	7	10	6	2
NAC	24	10	5	10	6	5	3
omega-3	20	6	7	8	6	5	2

研究類型分布

研究類型	文獻數	佔比
Meta-Analysis	37	4.8%
Systematic Review	16	2.1%
RCT	5	0.7%
Clinical Trial	1	0.1%
Observational	13	1.7%
Review	106	13.8%
Case Report	49	6.4%
Other	539	70.4%

近期重要文獻

Level 1 證據（Meta-Analysis / Systematic Review）

1. Systematic Review of Nutrients’ Impact on Cognition and School Performance in School-Aged Children in Sub-Saharan Africa. — Nutrition reviews, 2026-03-13
   • 功效分類：cardiovascular, cognitive
2. Effectiveness and safety of bone protective interventions to mitigate bone loss and skeletal fractures experienced by patients with non-metastatic breast cancer: a systematic review and meta-analysis. — Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026-02-16
   • 功效分類：musculoskeletal
3. Nutritional Adequacy and Dietary Assessment Approaches in Institutionalised Older Adults Living in Long-Term Care Settings: A Systematic Review (2004-2024). — Nutrients, 2025-12-23
   • 功效分類：metabolic, energy
4. The serum vitamin D status in adults with diabetic retinopathy: A systematic review and meta-analysis. — Journal of medical biochemistry, 2026-01-28
   • 功效分類：metabolic
5. Vitamin D deficiency and risk of surgical site infections: a systematic review and meta-analysis protocol. — Systematic reviews, 2026-03-11
   • 功效分類：other

Level 2 證據（RCT）

1. Vitamin D supplementation before in vitro fertilisation in women with polycystic ovary syndrome: multicentre, double blind, placebo controlled, randomised clinical trial. — BMJ (Clinical research ed.), 2026-02-17
   • 功效分類：sexual
2. Effect of standard versus long alimentary limb distal Roux-en-Y gastric bypass on weight loss and nutritional outcomes at 10 years in patients with BMI 50-60 kg/m2-a secondary analysis of a randomized clinical trial. — The British journal of surgery, 2025-12-24
   • 功效分類：cardiovascular, metabolic
3. Effects of acupuncture on improving hormonal and metabolic biochemical characteristics in polycystic ovary syndrome. — African journal of reproductive health, 2026-03-16
   • 功效分類：cardiovascular, immune, metabolic, sexual
4. Effect of vitamin D as Nutrition Supplement on Patients with Prolonged Ventilation due to Ventilator Associated Pneumonia and Sepsis Followed Severe Traumatic Lung Contusion: A Randomized Controlled Trial. — La Clinica terapeutica, 2026-01-01
   • 功效分類：other
5. Maternal supplementation of vitamin B — BMJ paediatrics open, 2026-03-18
   • 功效分類：other

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